SCHEMBL28720952

SCHEMBL28720952

C#CC(O)Cc1ccc(Br)cc1

nearest known ligand 0.45

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PYCR1 P32322 6/20 0.44
ESR1 P03372 1/20 0.40
ESR2 Q92731 1/20 0.40
MAOB P27338 1/20 0.39
ACACB O00763 1/20 0.38
MME P08473 2/20 0.37
HTR2A P28223 1/20 0.35
TAAR1 Q96RJ0 1/20 0.35
PPARG P37231 1/20 0.35
PPARA Q07869 1/20 0.35
SLC18A3 Q16572 1/20 0.35
IDO1 P14902 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8842181 0.79 MAOA (0.46) PYCR1ESR1ESR2MAOBTAAR1
SCHEMBL20488218 0.79 SLC6A4 (0.48) PYCR1ESR1ESR2ACACBTAAR1
SCHEMBL28634122 0.79 PYCR1 (0.40) PYCR1ESR1ESR2ACACBTAAR1
SCHEMBL134502 0.78 MAOB (0.47) MAOBTAAR1
SCHEMBL9793910 0.78 MAOB (0.47) MAOBTAAR1
SCHEMBL2298190 0.75 HTR2A (0.42) ACACBMMEHTR2ATAAR1PPARG
SCHEMBL20489213 0.75 LDHA (0.53) PYCR1ACACBIDO1
SCHEMBL7100971 0.75 SLC6A4 (0.54)
SCHEMBL29493531 0.75 PYCR1 (0.44) PYCR1ESR1ESR2MAOBTAAR1
SCHEMBL9349134 0.72 LTA4H (0.52) ACACBPPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114409501-B Method for preparing propargyl alcohol compound by taking pinacol borane as hydrogen source 云南民族大学 2024-05-10 CN disclosed
CN-114409501-A Method for preparing propargyl alcohol compound by taking pinacol borane as hydrogen source 云南民族大学 2022-04-29 CN disclosed