Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 4/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17150217 | 0.87 | NUDT1 (0.51) | NUDT1TBXAS1DPP4MKNK1MKNK2 | |
| SCHEMBL28734813 | 0.86 | NUDT1 (0.49) | NUDT1TBXAS1CDC7DBF4TSHR | |
| SCHEMBL2563447 | 0.82 | NUDT1 (0.47) | NUDT1TBXAS1CDC7DBF4TSHR | |
| SCHEMBL16093320 | 0.80 | TSHR (0.61) | TBXAS1TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL3605826 | 0.80 | TP53 (0.45) | NUDT1TBXAS1CDC7DBF4TSHR | |
| SCHEMBL17961067 | 0.79 | LMNA (0.57) | TSHRALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL29837473 | 0.77 | TSHR (0.60) | NUDT1CDC7DBF4TSHRALDH1A1 | |
| SCHEMBL3515887 | 0.77 | TSHR (0.60) | NUDT1CDC7DBF4TSHRALDH1A1 | |
| SCHEMBL5422256 | 0.76 | ALDH1A1 (0.43) | NUDT1TBXAS1CDC7DBF4TSHR | |
| SCHEMBL3290788 | 0.76 | TSHR (0.50) | NUDT1CDC7DBF4TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114341127-A | Aminopyrazine compounds as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-04-12 | — | — | CN | disclosed |