Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2873636 | 1.00 | MEN1 (0.43) | MEN1KMT2ACYP1B1OPRL1SCD | |
| SCHEMBL13093465 | 0.84 | OPRL1 (0.50) | MEN1KMT2ACYP1B1OPRL1ALDH1A1 | |
| SCHEMBL3897910 | 0.83 | L3MBTL1 (0.44) | CYP1B1SCDALDH1A1MAPTLMNA | |
| SCHEMBL2868031 | 0.82 | OPRL1 (0.45) | OPRL1CYP2D6CCR1RORC | |
| SCHEMBL2868029 | 0.82 | OPRL1 (0.45) | OPRL1CYP2D6CCR1RORC | |
| SCHEMBL520984 | 0.81 | SIRT6 (0.41) | KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL520983 | 0.81 | SIRT6 (0.41) | KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL1769324 | 0.78 | PGR (0.46) | MEN1KMT2ASCDALDH1A1MAPT | |
| SCHEMBL2814643 | 0.75 | ALDH1A1 (0.44) | MEN1KMT2ASCDALDH1A1MAPT | |
| SCHEMBL3047350 | 0.75 | PGR (0.43) | MEN1KMT2ASCDALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1811998-B1 | TRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2010-10-20 | — | — | EP | disclosed |
| US-7645775-B2 | Triazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-01-12 | — | — | US | disclosed |
| US-20070270410-A1 | Triazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2007-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270410-A1 | Triazoles useful as inhibitors of protein kinases | MAP3K20, MAP3K3, MAP3K1 | MEN1 2572/4885KMT2A 1446/4885CYP1B1 2856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.