SCHEMBL28752013

SCHEMBL28752013

Brc1ccc(-c2ccccc2)cc1[Si](c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.41
MAPK1 P28482 2/20 0.41
CRHBP P24387 1/20 0.39
CRHR2 Q13324 1/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
NFKB1 P19838 1/20 0.39
NFKB2 Q00653 1/20 0.39
RELA Q04206 1/20 0.39
ALOX5 P09917 1/20 0.36
MEN1 O00255 2/20 0.36
LMNA P02545 2/20 0.36
MAPT P10636 2/20 0.36
HTT P42858 2/20 0.36
KMT2A Q03164 2/20 0.36
APAF1 O14727 1/20 0.36
THRB P10828 1/20 0.36
XBP1 P17861 1/20 0.36
PTBP1 P26599 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4572772 0.80 CRHBP (0.42) ALDH1A1MAPK1CRHBPCRHR2NPC1
SCHEMBL16115917 0.78 NPC1 (0.41) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL4572727 0.76 ALDH1A1 (0.38) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL7650488 0.74 ALDH1A1 (0.37) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL29625371 0.73 ALDH1A1 (0.58) ALDH1A1MAPK1CRHBPCRHR2NPC1
SCHEMBL3297823 0.73 MEN1 (0.46) ALDH1A1ALOX5MEN1KMT2AKMO
SCHEMBL13766205 0.73 MAOA (0.44) ALDH1A1MAPK1ALOX5MEN1LMNA
SCHEMBL27403956 0.72 CRHBP (0.56) ALDH1A1MAPK1CRHBPCRHR2NPC1
SCHEMBL3889979 0.71 ALDH1A1 (0.53) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL9319701 0.71 ALDH1A1 (0.53) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114456204-A Light emitting diode and amine compound used therefor 三星显示有限公司 2022-05-10 CN disclosed