Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | NAAA | Q02083 | 3/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MLYCD | O95822 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27619583 | 0.92 | SMN1; SMN2 (0.58) | SMN1; SMN2NAAAHDAC3HDAC11HDAC8 | |
| SCHEMBL1855176 | 0.91 | NAAA (0.68) | SMN1; SMN2NAAAHDAC3HDAC11HDAC8 | |
| SCHEMBL5044262 | 0.87 | L3MBTL1 (0.62) | SMN1; SMN2NAAAHDAC3HDAC11HDAC8 | |
| SCHEMBL27619626 | 0.87 | GAA (0.58) | SMN1; SMN2NAAAHDAC1SLC6A5ROCK2 | |
| SCHEMBL5045292 | 0.87 | SMN1; SMN2 (0.53) | SMN1; SMN2NAAAHDAC3HDAC11HDAC8 | |
| SCHEMBL27601089 | 0.87 | NAAA (0.62) | SMN1; SMN2NAAAHDAC3HDAC11HDAC8 | |
| SCHEMBL5044022 | 0.86 | MRGPRX4 (0.56) | SMN1; SMN2NAAAHDAC3HDAC1HDAC2 | |
| SCHEMBL1856260 | 0.86 | ALDH1A1 (0.53) | SMN1; SMN2NAAAHDAC3HDAC11HDAC8 | |
| SCHEMBL27601103 | 0.85 | NAAA (0.56) | SMN1; SMN2NAAAHDAC3HDAC11HDAC8 | |
| SCHEMBL5040331 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2NAAAHDAC3HDAC11HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100410236-C | Substituted methylene amide derivatives as protein tyrosine phosphatase modulators | APPLIED RESEARCH SYSTEMS (CH) | 2008-08-13 | — | — | CN | disclosed |
| CN-1633410-A | Substituted methylene amide derivatives as protein tyrosine phosphatase modulators | APPLIED RESEARCH SYSTEMS (AN) | 2005-06-29 | — | — | CN | disclosed |