Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.56 |
| ▸ | MLYCD | O95822 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NAAA | Q02083 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048864 | 0.92 | ALDH1A1 (0.62) | MRGPRX4MLYCDALDH1A1POLBNAAA | |
| SCHEMBL1852697 | 0.91 | MLYCD (0.58) | MRGPRX4MLYCDALDH1A1POLBNAAA | |
| SCHEMBL1853826 | 0.90 | MLYCD (0.64) | MLYCDALDH1A1NAAASMN1; SMN2HDAC3 | |
| SCHEMBL1855176 | 0.87 | NAAA (0.68) | MLYCDNAAASMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL28752189 | 0.86 | SMN1; SMN2 (0.57) | MLYCDNAAASMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL27601089 | 0.85 | NAAA (0.62) | ALDH1A1NAAASMN1; SMN2HDAC3NAMPT | |
| SCHEMBL5044180 | 0.85 | MRGPRX4 (0.48) | MRGPRX4MLYCDALDH1A1POLBNAAA | |
| SCHEMBL1858157 | 0.84 | TMEM97 (0.53) | MRGPRX4MLYCDALDH1A1POLBNAAA | |
| SCHEMBL27619626 | 0.83 | GAA (0.58) | NAAASMN1; SMN2HDAC1 | |
| SCHEMBL5045292 | 0.83 | SMN1; SMN2 (0.53) | MLYCDNAAASMN1; SMN2HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |
| EP-1470102-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-10-27 | — | — | EP | claimed |
| WO-2003064376-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-08-07 | — | — | WO | claimed |