SCHEMBL28753181

SCHEMBL28753181

CCOC(=O)c1ccc2c(cnn2COCC[Si](C)(C)C)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.41
MAPT P10636 2/20 0.41
ALDH1A1 P00352 1/20 0.41
PPARG P37231 1/20 0.41
NCOA2 Q15596 1/20 0.41
NCOA1 Q15788 1/20 0.41
SIRT2 Q8IXJ6 4/20 0.41
SIRT1 Q96EB6 4/20 0.41
EGFR P00533 1/20 0.41
ERBB2 P04626 1/20 0.41
NPC1 O15118 2/20 0.40
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA7 P43166 1/20 0.39
CA9 Q16790 1/20 0.39
CA14 Q9ULX7 1/20 0.39
DGAT1 O75907 1/20 0.39
MAOA P21397 1/20 0.39
MAOB P27338 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29627173 1.00 RAB9A (0.41) RAB9AMAPTALDH1A1PPARGNCOA2
SCHEMBL24271183 0.89 MAOA (0.44) RAB9AMAPTALDH1A1PPARGNPC1
SCHEMBL29395869 0.89 MAOA (0.44) RAB9AMAPTALDH1A1PPARGNPC1
SCHEMBL29395877 0.86 PLA2G4A (0.45) NPC1DGAT1MAOAMAOB
SCHEMBL23165875 0.86 PLA2G4A (0.45) NPC1DGAT1MAOAMAOB
SCHEMBL3644842 0.85 NPC1 (0.54) ALDH1A1NPC1DGAT1MAOAMAOB
SCHEMBL30908132 0.82 DGAT1 (0.39) RAB9AALDH1A1NPC1DGAT1MAOB
SCHEMBL904672 0.82 MAPT (0.48) RAB9AMAPTALDH1A1PPARGNCOA2
SCHEMBL17845097 0.81 NPC1 (0.39) MAPTPPARGNPC1DGAT1MAOA
SCHEMBL2965865 0.80 CYP2C9 (0.42) RAB9AMAPTALDH1A1NPC1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114466844-B N- (1H-imidazol-2-yl) benzamide compound and pharmaceutical composition comprising same as active ingredient 康佳诺医疗科技发展有限公司 2025-02-18 CN disclosed
CN-114466844-A N- (1H-imidazol-2-yl) benzamide compounds and pharmaceutical compositions containing the same as active ingredient 康佳诺医疗科技发展有限公司 2022-05-10 CN disclosed