Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | THRB | P10828 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.35 |
| ▸ | RAD52 | P43351 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7762840 | 0.84 | INSR (0.56) | INSRMAPTTHRBRECQLALDH1A1 | |
| SCHEMBL3643981 | 0.82 | APP (0.42) | INSRMAPTTHRBRECQLALDH1A1 | |
| SCHEMBL3214133 | 0.81 | APP (0.41) | INSRMAPTTHRBRECQLALDH1A1 | |
| SCHEMBL5067726 | 0.80 | APP (0.40) | INSRMAPTTHRBRECQLALDH1A1 | |
| SCHEMBL5716206 | 0.77 | APP (0.38) | INSRMAPTTHRBRECQLALDH1A1 | |
| SCHEMBL1402286 | 0.76 | ALDH1A1 (0.49) | INSRMAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3766308 | 0.72 | ADRB2 (0.71) | INSRMAPTTHRBALDH1A1SMN1; SMN2 | |
| SCHEMBL3766310 | 0.72 | ADRB2 (0.71) | INSRMAPTTHRBALDH1A1SMN1; SMN2 | |
| SCHEMBL7762854 | 0.72 | ADRB2 (0.54) | INSRMAPTTHRBRECQLALDH1A1 | |
| SCHEMBL10974237 | 0.71 | INSR (0.46) | INSRMAPTALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1681470-A | Agent for dyeing keratinous fibres | HENKEL KGAA (DE) | 2005-10-12 | — | — | CN | disclosed |