Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR known ✓ | P06213 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | SNCA | P37840 | 2/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3214133 | 0.95 | APP (0.41) | APPSNCATNFNOD1MEN1 | |
| SCHEMBL3643981 | 0.94 | APP (0.42) | APPSNCATNFNOD1MEN1 | |
| SCHEMBL5067726 | 0.93 | APP (0.40) | APPSNCATNFNOD1MEN1 | |
| SCHEMBL7049507 | 0.86 | SMN1; SMN2 (0.45) | APPSNCATNFNOD1MEN1 | |
| SCHEMBL4625707 | 0.81 | SNCA (0.50) | APPSNCATNFNOD1MEN1 | |
| SCHEMBL28755569 | 0.77 | INSR (0.44) | MEN1KMT2APOLBNPC1RAB9A | |
| SCHEMBL3217539 | 0.77 | — | — | |
| SCHEMBL28065596 | 0.73 | CYP2A6 (0.57) | POLBPTGS2MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7049508 | 0.72 | APP (0.33) | APPSNCATNFNOD1MEN1 | |
| SCHEMBL7050705 | 0.72 | ALDH1A1 (0.47) | APPSNCATNFNOD1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682229-A1 | AGENT FOR MINIMISING THE COLORATION OF THE SKIN | Henkel Kommanditgesellschaft auf Aktien (DE) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005034896-A1 | AGENT FOR MINIMISING THE COLORATION OF THE SKIN | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2005-04-21 | — | — | WO | disclosed |