Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 7/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3866410 | 0.81 | LMNA (0.54) | POLBLMNACYP1A2CYP2C19CYP3A4 | |
| SCHEMBL12569622 | 0.74 | TDP1 (0.54) | POLBKMT2AMEN1NPC1SMN1; SMN2 | |
| SCHEMBL1221521 | 0.74 | ALDH1A1 (0.54) | KMT2AMEN1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL7381497 | 0.73 | TUBB4A (0.46) | LMNAKMT2AMEN1SMN1; SMN2KDM4E | |
| SCHEMBL12086947 | 0.73 | POLB (0.52) | POLBLMNAKMT2AMEN1NPC1 | |
| SCHEMBL3224251 | 0.72 | NPC1 (0.81) | POLBLMNACYP1A2CYP2C19CYP3A4 | |
| SCHEMBL30205105 | 0.72 | NPC1 (0.81) | POLBLMNACYP1A2CYP2C19CYP3A4 | |
| SCHEMBL257274 | 0.72 | MAPT (0.62) | POLBLMNACYP1A2CYP2C19CYP3A4 | |
| SCHEMBL7802440 | 0.72 | HPGD (0.62) | POLBLMNACYP1A2CYP2C19CYP3A4 | |
| SCHEMBL7939201 | 0.72 | MAPT (0.64) | POLBLMNACYP1A2CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1856473-A | Isoquinolinone potassium channel inhibitors | MERCK & CO INC (US) | 2006-11-01 | — | — | CN | disclosed |