Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3480817 | 0.90 | LMNA (0.57) | LMNAALDH1A1HTTCYP1A2HPGD | |
| SCHEMBL13248615 | 0.86 | ALDH1A1 (0.58) | LMNAALDH1A1HTTCYP1A2HPGD | |
| SCHEMBL28757948 | 0.81 | POLB (0.49) | LMNAALDH1A1HTTCYP1A2HPGD | |
| SCHEMBL7043694 | 0.78 | ALDH1A1 (0.61) | LMNAALDH1A1HTTCYP1A2HPGD | |
| SCHEMBL3480945 | 0.77 | ALDH1A1 (0.71) | LMNAALDH1A1HTTCYP1A2HPGD | |
| SCHEMBL6046657 | 0.77 | ALDH1A1 (0.56) | LMNAALDH1A1HTTCYP1A2HPGD | |
| SCHEMBL10293784 | 0.74 | LMNA (0.68) | LMNAALDH1A1HTTCYP1A2HPGD | |
| SCHEMBL699230 | 0.74 | ALDH1A1 (0.71) | LMNAALDH1A1HTTCYP1A2HPGD | |
| SCHEMBL10397387 | 0.74 | HTT (0.71) | LMNAALDH1A1HTTCYP1A2HPGD | |
| SCHEMBL10390871 | 0.74 | MTNR1A (0.47) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781457-B2 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-08-24 | — | — | US | disclosed |
| EP-1667977-A4 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-1667977-A1 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005030727-A1 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2005-04-07 | — | — | WO | disclosed |