Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28001907 | 0.88 | KDM4E (0.37) | KDM4ECA12CA1CA2CA7 | |
| SCHEMBL27722737 | 0.81 | ESR1 (0.37) | ESR1HIF1ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL28254578 | 0.79 | ACHE (0.41) | KDM4ENPC1RAB9AESR1HIF1A | |
| SCHEMBL7745278 | 0.78 | CA12 (0.40) | KDM4ECA12CA1CA2CA7 | |
| SCHEMBL28772952 | 0.77 | ALDH1A1 (0.51) | SMN1; SMN2LMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL27754997 | 0.76 | CYP1A2 (0.44) | KDM4EESR1HIF1ASMN1; SMN2LMNA | |
| SCHEMBL28758016 | 0.75 | BCL9 (0.48) | KDM4ECA12CA1CA2CA7 | |
| SCHEMBL16566851 | 0.74 | SMN1; SMN2 (0.59) | KDM4ESMN1; SMN2LMNA | |
| SCHEMBL28001905 | 0.73 | GAA (0.53) | KDM4ESMN1; SMN2LMNATP53ALDH1A1 | |
| SCHEMBL534024 | 0.72 | PTGS2 (0.52) | KDM4ENPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101679359-B | Quinolines and their therapeutic use | ARGENTA DISCOVERY LTD | 2013-03-06 | — | — | CN | disclosed |
| CN-101316591-B | Quinoline compound and pharmaceutical application thereof | ARGENTA ORAL THERAPEUTICS LTD. (GB) | 2012-02-01 | — | — | CN | disclosed |
| CN-101715441-A | Quinoline derivatives as CRTH2 receptor ligands | ARGENTA DISCOVERY LTD | 2010-05-26 | — | — | CN | disclosed |
| CN-101679359-A | Quinolines and their therapeutic use | ARGENTA DISCOVERY LTD | 2010-03-24 | — | — | CN | disclosed |
| CN-101316591-A | Quinolines and their therapeutic use | ARGENTA DISCOVERY LTD (GB) | 2008-12-03 | — | — | CN | disclosed |