Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.38 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27731002 | 0.87 | SIRT2 (0.45) | PARP1SIRT2KDM4EMAP4K4PIM1 | |
| SCHEMBL27940784 | 0.79 | MEN1 (0.52) | PARP1MEN1KMT2ACHEK1MAP4K4 | |
| SCHEMBL27731011 | 0.79 | HTT (0.47) | PARP1CHEK1MAP4K4LCKCSF1R | |
| SCHEMBL27731028 | 0.78 | KEAP1 (0.44) | PARP1SIRT2MEN1KMT2AKDM4E | |
| SCHEMBL29618430 | 0.74 | BCAT2 (0.54) | PARP1SIRT2CHEK1PARP10NPC1 | |
| SCHEMBL15412857 | 0.74 | PARP1 (0.58) | PARP1MEN1KMT2APKMCHEK1 | |
| SCHEMBL17425093 | 0.69 | LMNA (0.53) | LMNA | |
| SCHEMBL9118446 | 0.69 | ELANE (0.48) | PARP1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL27940786 | 0.68 | IKBKB (0.47) | PARP1MEN1KMT2AKDM4EPKM | |
| SCHEMBL27940858 | 0.67 | HRH3 (0.48) | PARP1KDM4EKEAP1NFE2L2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101186586-A | N,N'-difluorophenyl derivative of 4-methoxyl-1,3-phthalamide and use thereof | UNIV TIANJIN TECHNOLOGY (CN) | 2008-05-28 | — | — | CN | claimed |
| CN-101186586-B | N,N'-difluorophenyl derivative of 4-methoxyl-1,3-phthalamide and use thereof | UNIV TIANJIN TECHNOLOGY | 2010-06-30 | — | — | CN | disclosed |
| CN-101186586-A | N,N'-difluorophenyl derivative of 4-methoxyl-1,3-phthalamide and use thereof | UNIV TIANJIN TECHNOLOGY (CN) | 2008-05-28 | — | — | CN | disclosed |