SCHEMBL28776282

SCHEMBL28776282

COC(=O)C(F)(Cl)C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.39
DGAT1 O75907 1/20 0.36
GAA P10253 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.32
KCNN4 O15554 1/20 0.32
MEN1 O00255 3/20 0.32
KMT2A Q03164 3/20 0.32
MAPT P10636 3/20 0.32
LMNA P02545 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.31
NPC1 O15118 1/20 0.31
MAPK1 P28482 1/20 0.31
RAB9A P51151 1/20 0.31
NPSR1 Q6W5P4 1/20 0.30
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2C9 P11712 1/20 0.30
CYP2C19 P33261 1/20 0.30
GLA P06280 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4854047 0.78
SCHEMBL9806073 0.78 DGAT1 (0.39) ALDH1A1DGAT1GAAL3MBTL1KCNN4
SCHEMBL3592898 0.78
SCHEMBL132957 0.78
SCHEMBL23869987 0.76
SCHEMBL10496132 0.75 ALDH1A1 (0.31) ALDH1A1DGAT1
Fluoride Ion SCHEMBL176967 0.74 DGAT1 (0.36) ALDH1A1DGAT1L3MBTL1KCNN4MAPT
Potassium Fluoride SCHEMBL27832151 0.74 DGAT1 (0.36) ALDH1A1DGAT1L3MBTL1KCNN4MAPT
SCHEMBL1240770 0.74 DGAT1 (0.36) ALDH1A1DGAT1GAAL3MBTL1KCNN4
SCHEMBL31272158 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109535001-B Method for preparing fluorocarboxylic acid ester 昊华气体有限公司 2022-07-05 CN disclosed