Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | METAP2 | P50579 | 3/20 | 0.47 |
| ▸ | BRAF | P15056 | 4/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | KIF5B | P33176 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 3/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2880810 | 0.88 | METAP2 (0.47) | BRD4METAP2BRAFPIK3CAPIK3CD | |
| SCHEMBL3435046 | 0.83 | BRD4 (0.56) | BRD4METAP2BRAFPIK3CAABL1 | |
| SCHEMBL28924973 | 0.81 | PIK3CA (0.56) | BRD4METAP2BRAFPIK3CAPIK3CD | |
| SCHEMBL15876525 | 0.76 | METAP2 (0.44) | BRD4METAP2BRAFPIK3CAPIK3CD | |
| SCHEMBL3435497 | 0.76 | METAP2 (0.46) | BRD4METAP2BRAFPIK3CAPIK3CD | |
| SCHEMBL3435032 | 0.75 | PIK3CA (0.42) | BRD4METAP2BRAFPIK3CAPIK3CD | |
| SCHEMBL3433766 | 0.75 | METAP2 (0.51) | BRD4METAP2BRAFPIK3CAPIK3CD | |
| SCHEMBL3432778 | 0.74 | METAP2 (0.45) | BRD4METAP2BRAFPIK3CAPIK3CD | |
| SCHEMBL28635804 | 0.72 | BRAF (0.51) | BRD4METAP2BRAFPIK3CAPIK3CD | |
| SCHEMBL560480 | 0.69 | PIK3CA (0.71) | BRD4BRAFPIK3CAPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118367-A2 | ANTIVIRAL PYRIMIDINES | PROGENICS PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |