Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2879628 | 0.88 | BRD4 (0.50) | METAP2BRD4PIK3CAPIK3CDPIK3CB | |
| SCHEMBL3433766 | 0.83 | METAP2 (0.51) | METAP2BRD4PIK3CAPIK3CDPIK3CB | |
| SCHEMBL3435032 | 0.82 | PIK3CA (0.42) | METAP2BRD4PIK3CAPIK3CDPIK3CB | |
| SCHEMBL28924973 | 0.78 | PIK3CA (0.56) | METAP2BRD4PIK3CAPIK3CDPIK3CB | |
| SCHEMBL15876525 | 0.77 | METAP2 (0.44) | METAP2BRD4PIK3CAPIK3CDPIK3CB | |
| SCHEMBL3435046 | 0.76 | BRD4 (0.56) | METAP2BRD4PIK3CABRAFCCNA2 | |
| SCHEMBL28635804 | 0.75 | BRAF (0.51) | METAP2BRD4PIK3CAPIK3CDPIK3CB | |
| SCHEMBL3435497 | 0.75 | METAP2 (0.46) | METAP2BRD4PIK3CAPIK3CDPIK3CB | |
| SCHEMBL3432778 | 0.73 | METAP2 (0.45) | METAP2BRD4PIK3CAPIK3CDPIK3CB | |
| SCHEMBL28961950 | 0.70 | BRAF (0.61) | METAP2BRD4PIK3CABRAFMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059788-A1 | PYRAZOLOPYRIDINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-05-27 | — | — | WO | claimed |
| CN-106659765-B | Use of dianhydrogalactitol and analogs or derivatives thereof for treating non-small cell lung cancer and ovarian cancer | 德玛医药 | 2021-08-13 | — | — | CN | disclosed |