Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.40 |
| ▸ | PPARG | P37231 | 7/20 | 0.38 |
| ▸ | PPARA | Q07869 | 6/20 | 0.38 |
| ▸ | PPARD | Q03181 | 5/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27867715 | 0.91 | RORC (0.40) | RORCPPARGPPARAPPARDSRD5A2 | |
| SCHEMBL27936027 | 0.91 | PPARG (0.39) | RORCPPARGPPARAPPARDSRD5A2 | |
| SCHEMBL27884298 | 0.90 | PPARG (0.36) | RORCPPARGPPARAPPARDCCR2 | |
| SCHEMBL27884217 | 0.89 | RORC (0.40) | RORCPPARGPPARAPPARDSRD5A2 | |
| SCHEMBL28800059 | 0.89 | PPARG (0.36) | RORCPPARGPPARAPPARDPTGER4 | |
| SCHEMBL27867734 | 0.89 | CCR2 (0.39) | RORCPPARGPPARAPPARDPTGER4 | |
| SCHEMBL27936053 | 0.89 | RORC (0.38) | RORCPPARGPPARAPPARDSRD5A2 | |
| SCHEMBL28797215 | 0.88 | DHCR7 (0.41) | PPARGPPARAPPARDDHCR7 | |
| SCHEMBL27884197 | 0.88 | PTPN1 (0.43) | RORCPPARGPPARAPPARDSRD5A2 | |
| SCHEMBL28946335 | 0.87 | PPARG (0.36) | RORCPPARGPPARAPPARDCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103554006-A | Use of indole derivatives as nurr-1 activators for the application thereof as a medicament for the treatment of parkinson's disease | FOURNIER LAB SA | 2014-02-05 | — | — | CN | disclosed |
| CN-102596906-A | Use of indole derivatives as NURR-1 activators as agents for the treatment of Parkinson's disease | FOURNIER LAB SA | 2012-07-18 | — | — | CN | disclosed |