Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.36 |
| ▸ | PPARA | Q07869 | 8/20 | 0.36 |
| ▸ | PPARD | Q03181 | 7/20 | 0.36 |
| ▸ | RORC | P51449 | 3/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27884298 | 0.93 | PPARG (0.36) | PPARGPPARAPPARDRORCCCR2 | |
| SCHEMBL27867734 | 0.92 | CCR2 (0.39) | PPARGPPARAPPARDRORCCCR2 | |
| SCHEMBL28800067 | 0.89 | RORC (0.40) | PPARGPPARAPPARDRORCCCR2 | |
| SCHEMBL28946031 | 0.89 | ACLY (0.35) | PPARGPPARAPPARDMEN1ALDH1A1 | |
| SCHEMBL12096899 | 0.85 | PPARG (0.51) | PPARGPPARAPPARDRORCCCR2 | |
| SCHEMBL28946335 | 0.85 | PPARG (0.36) | PPARGPPARAPPARDRORCCCR2 | |
| SCHEMBL27884203 | 0.83 | PPARG (0.34) | PPARGPPARAPPARDCCR2 | |
| SCHEMBL27867800 | 0.83 | PPARG (0.38) | PPARGPPARAPPARDRORC | |
| SCHEMBL28800079 | 0.82 | PPARG (0.36) | PPARGPPARAPPARDRORCCCR2 | |
| SCHEMBL27867715 | 0.81 | RORC (0.40) | PPARGPPARAPPARDRORCPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103554006-A | Use of indole derivatives as nurr-1 activators for the application thereof as a medicament for the treatment of parkinson's disease | FOURNIER LAB SA | 2014-02-05 | — | — | CN | disclosed |
| CN-102596906-A | Use of indole derivatives as NURR-1 activators as agents for the treatment of Parkinson's disease | FOURNIER LAB SA | 2012-07-18 | — | — | CN | disclosed |