Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.45 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28800162 | 0.90 | HPGD (0.50) | HTTHPGDALDH1A1MAPTGAA | |
| SCHEMBL28800159 | 0.89 | KMT2A (0.56) | HTTHPGDALDH1A1MAPTGAA | |
| SCHEMBL28800137 | 0.89 | POLB (0.52) | HTTHPGDALDH1A1MAPTGAA | |
| SCHEMBL27769609 | 0.88 | ALDH1A1 (0.66) | HTTHPGDALDH1A1MAPTCYP2C19 | |
| SCHEMBL28800153 | 0.85 | MAPT (0.46) | HTTHPGDALDH1A1MAPTCYP2C19 | |
| SCHEMBL28800120 | 0.84 | POLB (0.52) | HTTHPGDALDH1A1MAPTGAA | |
| SCHEMBL29800446 | 0.80 | GABRA2 (0.52) | HTTHPGDALDH1A1MAPTGAA | |
| SCHEMBL28800116 | 0.80 | GABRA2 (0.52) | HTTHPGDALDH1A1MAPTGAA | |
| SCHEMBL15004739 | 0.80 | ALDH1A1 (0.76) | HTTHPGDALDH1A1MAPTCYP2C19 | |
| SCHEMBL28800118 | 0.80 | HTT (0.48) | HTTHPGDALDH1A1MAPTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114790176-A | Imidazole compound and preparation method and application thereof | 武汉人福创新药物研发中心有限公司 | 2022-07-26 | — | — | CN | disclosed |