SCHEMBL28802172

SCHEMBL28802172

CC(=O)OC(C)(C)Cc1cccc(C2(C)OCCO2)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSD P07339 4/20 0.35
BACE1 P56817 4/20 0.35
CTSK P43235 3/20 0.34
HCAR3 P49019 1/20 0.33
HCAR2 Q8TDS4 1/20 0.33
SMN1; SMN2 Q16637 3/20 0.32
MAPK1 P28482 1/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
TSHR P16473 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.31
SLC7A5 Q01650 1/20 0.31
CYP3A4 P08684 2/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C9 P11712 1/20 0.31
NFKB1 P19838 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1706213 0.81 MTNR1A (0.36) HCAR3HCAR2SMN1; SMN2MAPK1ALDH1A1
SCHEMBL11738540 0.79 LMNA (0.36) CTSDBACE1HCAR3HCAR2SMN1; SMN2
SCHEMBL27974805 0.76 ALDH1A1 (0.37) HCAR3HCAR2SMN1; SMN2MAPK1ALDH1A1
SCHEMBL1706364 0.75 AKR1B1 (0.43) HCAR3HCAR2ALDH1A1LMNAGAA
SCHEMBL856097 0.74 OPRM1 (0.40) HCAR3HCAR2SMN1; SMN2MAPK1ALDH1A1
SCHEMBL27731652 0.74 MAOB (0.47) CTSKHCAR2CYP1A2CYP2D6CYP2C19
SCHEMBL27899553 0.73 TSHR (0.38) HCAR3HCAR2SMN1; SMN2MAPK1ALDH1A1
SCHEMBL1705855 0.73 GAA (0.44) HCAR3HCAR2SMN1; SMN2GAAL3MBTL1
SCHEMBL111212 0.72 ALDH1A1 (0.50) CTSKSMN1; SMN2ALDH1A1LMNACYP3A4
SCHEMBL507495 0.71 SMN1; SMN2 (0.44) SMN1; SMN2MAPK1ALDH1A1LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102803237-B Oxazole and thiazole derivatives as alx receptor agonists ACTELION PHARMACEUTICALS LTD 2014-09-24 CN disclosed
CN-102803237-A Oxazole and thiazole derivatives as alx receptor agonists ACTELION PHARMACEUTICALS LTD 2012-11-28 CN disclosed