Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.50 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.48 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.48 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL205655 | 0.84 | SMN1; SMN2 (0.53) | P2RX4L3MBTL1SMN1; SMN2MAPK1GAA | |
| SCHEMBL29549990 | 0.84 | SMN1; SMN2 (0.53) | P2RX4L3MBTL1SMN1; SMN2MAPK1GAA | |
| SCHEMBL6110992 | 0.81 | SMN1; SMN2 (0.44) | P2RX4NPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL6110401 | 0.80 | P2RX4 (0.64) | P2RX4SMN1; SMN2P2RX1P2RX3KMT2A | |
| SCHEMBL3719677 | 0.78 | BCHE (0.50) | P2RX4L3MBTL1SMN1; SMN2MAPK1P2RX1 | |
| SCHEMBL27785934 | 0.78 | P2RX4 (0.58) | P2RX4SMN1; SMN2MAPK1GAAPSEN1 | |
| SCHEMBL29639604 | 0.77 | SMN1; SMN2 (0.44) | P2RX4SMN1; SMN2MAPK1GAAP2RX1 | |
| SCHEMBL411007 | 0.77 | SMN1; SMN2 (0.44) | P2RX4SMN1; SMN2MAPK1GAAP2RX1 | |
| SCHEMBL29376182 | 0.77 | P2RX4 (0.44) | P2RX4SMN1; SMN2MAPK1P2RX1P2RX3 | |
| SCHEMBL3375661 | 0.77 | P2RX4 (0.44) | P2RX4SMN1; SMN2MAPK1P2RX1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109153646-B | Pyridine dicarboxamide derivatives as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2022-08-02 | — | — | CN | disclosed |