SCHEMBL28811550

SCHEMBL28811550

C=C(C(=O)OCC)N(C(=O)c1cc(F)c(Cl)cc1Cl)C1CC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 1/20 0.39
GAA P10253 2/20 0.35
CASP1 P29466 1/20 0.34
SMN1; SMN2 Q16637 5/20 0.34
TSHR P16473 3/20 0.34
KDM4E B2RXH2 3/20 0.34
POLB P06746 1/20 0.34
ALDH1A1 P00352 3/20 0.34
MAPT P10636 1/20 0.34
LMNA P02545 1/20 0.34
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
HPGD P15428 2/20 0.33
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
SLC6A2 P23975 1/20 0.32
SLC6A4 P31645 1/20 0.32
SLC6A3 Q01959 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2C19 P33261 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5257676 0.94 GAA (0.40) HSD11B1GAACASP1SMN1; SMN2TSHR
SCHEMBL5776783 0.75 HPGD (0.44) GAASMN1; SMN2TSHRPOLBALDH1A1
SCHEMBL28811552 0.74 HSD11B1 (0.36) HSD11B1GAASMN1; SMN2TSHRKDM4E
SCHEMBL14111349 0.71 MAPT (0.42) GAASMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL9562462 0.70 GAA (0.42) GAASMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL29754269 0.70 GAA (0.42) GAASMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL9211517 0.70 GAA (0.42) GAASMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL9720579 0.70 GAA (0.42) GAASMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL8335693 0.70 CYP4F2 (0.53) GAASMN1; SMN2TSHRMAPTLMNA
SCHEMBL28409540 0.70 GAA (0.37) GAACASP1SMN1; SMN2MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114849634-B Reaction kettle for amination reaction and use method thereof 江苏飞宇医药科技股份有限公司 2022-10-25 CN disclosed
CN-114849634-A Reaction kettle for amination reaction and use method thereof 江苏飞宇医药科技股份有限公司 2022-08-05 CN disclosed