SCHEMBL28816

SCHEMBL28816

N/C(=C\C=C\C(=O)O)C(=O)O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.40
TP53 P04637 1/20 0.40
EGLN1 Q9GZT9 1/20 0.40
EGLN3 Q9H6Z9 1/20 0.40
TDP1 Q9NUW8 4/20 0.39
ALDH1A1 P00352 4/20 0.39
HSD17B10 Q99714 3/20 0.39
ALOX15 P16050 2/20 0.39
RECQL P46063 2/20 0.39
GABRR1 P24046 2/20 0.35
GABRR2 P28476 2/20 0.35
BLM P54132 2/20 0.35
GABRR3 A8MPY1 1/20 0.35
LMNA P02545 1/20 0.35
APEX1 P27695 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
MAPT P10636 2/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2C9 P11712 1/20 0.34
HPGD P15428 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1332095 1.00 TSHR (0.40) TSHRTP53EGLN1EGLN3TDP1
SCHEMBL28815 1.00 TSHR (0.40) TSHRTP53EGLN1EGLN3TDP1
SCHEMBL637960 0.74 LDHA (0.33) LDHALDHBACHE
SCHEMBL13176449 0.74 LDHA (0.33) LDHALDHBACHE
SCHEMBL14784817 0.74 LDHA (0.33) LDHALDHBACHE
SCHEMBL28895629 0.74
SCHEMBL454524 0.72 TSHR (0.44) TSHRTP53EGLN1EGLN3TDP1
SCHEMBL529628 0.72 TSHR (0.44) TSHRTP53EGLN1EGLN3TDP1
SCHEMBL19379407 0.72 TSHR (0.44) TSHRTP53EGLN1EGLN3TDP1
SCHEMBL454525 0.72 TSHR (0.44) TSHRTP53EGLN1EGLN3TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 131 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4658402-A1 METAL ORGANIC FRAMEWORKS POLYMORPHISM FOR ADSORPTION PROFILE TUNING Centre National de la Recherche Scientifique (FR) 2025-12-10 EP claimed
WO-2024160984-A1 METAL ORGANIC FRAMEWORKS POLYMORPHISM FOR ADSORPTION PROFILE TUNING CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2024-08-08 WO claimed
EP-4410419-A1 METAL ORGANIC FRAMEWORKS POLYMORPHISM FOR ADSORPTION PROFILE TUNING Centre National de la Recherche Scientifique (FR) 2024-08-07 EP claimed
US-20190292405-A1 SLURRIES FOR CHEMICAL MECHANICAL POLISHING OF COBALT CONTAINING SUBSTRATES FUJIMI INCORPORATED (JP) 2019-09-26 US claimed
CN-103221033-A Compositions for gastric delivery of active agents YISSUM RES DEV CO 2013-07-24 CN claimed
EP-2608771-A1 COMPOSITIONS FOR GASTRIC DELIVERY OF ACTIVE AGENTS Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (IL) 2013-07-03 EP claimed
WO-2012025921-A1 COMPOSITIONS FOR GASTRIC DELIVERY OF ACTIVE AGENTS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2012-03-01 WO claimed
US-20260115215-A1 NICOTINAMIDE MONONUCLEOTIDE DERIVATIVES AND USE THEREOF IN THE TREATMENT AND PREVENTION OF A RED BLOOD CELL DISORDER NUVAMID SA (CH) 2026-04-30 US disclosed
US-20260108550-A1 NICOTINAMIDE MONONUCLEOTIDE DERIVATIVES AND USE THEREOF IN THE TREATMENT AND PREVENTION OF A RED BLOOD CELL DISORDER NUVAMID SA (CH) 2026-04-23 US disclosed
US-20260091051-A1 USE OF NMN FOR THE PREVENTION AND/OR TREATMENT OF PAIN, AND CORRESPONDING COMPOSITIONS NUVAMID SA (CH) 2026-04-02 US disclosed
US-20260063601-A1 PLASMA METABOLOME AS A PREDICTOR OF BIOLOGICAL AGING THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY (US) 2026-03-05 US disclosed
EP-4658402-A1 METAL ORGANIC FRAMEWORKS POLYMORPHISM FOR ADSORPTION PROFILE TUNING Centre National de la Recherche Scientifique (FR) 2025-12-10 EP disclosed
US-20250361531-A1 MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS AGAIN BIO APS (DK) 2025-11-27 US disclosed
WO-2015077414-A1 KYNURENINE PATHWAY BIOMARKERS PREDICTIVE OF ANTI-IMMUNE CHECKPOINT INHIBITOR RESPONSE DANA-FARBER CANCER INSTITUTE, INC. (US) 2015-05-28 WO disclosed
CN-103857440-A Conjugate-based antifungal and antibacterial prodrugs VYOME BIOSCIENCES 2014-06-11 CN disclosed
CN-103221033-A Compositions for gastric delivery of active agents YISSUM RES DEV CO 2013-07-24 CN disclosed
US-20130091932-A1 Process and Method for Broad Spectrum Amino Acid Challenged Urinary Organic Acids GENOVA DIAGNOSTICS, INC. 2013-04-18 US disclosed
US-20120231972-A1 Probe Compound for Detecting and Isolating Enzymes and Means and Methods Using the Same INSTITUTE OF CATALYSIS (CSIC) (ES) 2012-09-13 US disclosed
WO-2010105851-A1 PROBE COMPOUND FOR DETECTING AND ISOLATING ENZYMES AND MEANS AND METHODS USING THE SAME Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2010-09-23 WO disclosed
US-6432683-B1 Preparation of 2-aminomuconate from 2-aminophenol by coupled enzymatic dioxygenation and dehydrogenation reactions THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE 2002-08-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260108550-A1 NICOTINAMIDE MONONUCLEOTIDE DERIVATIVES AND USE THEREOF IN THE TREATMENT AND PREVENTION OF A RED BLOOD CELL DISORDER HBG1, KYNU, NNT TSHR 1711/4885TP53 4321/4885EGLN1 641/4885
US-20260115215-A1 NICOTINAMIDE MONONUCLEOTIDE DERIVATIVES AND USE THEREOF IN THE TREATMENT AND PREVENTION OF A RED BLOOD CELL DISORDER HBG1, HCCS, HBG2 TSHR 1635/4885TP53 3654/4885EGLN1 1127/4885
US-20260063601-A1 PLASMA METABOLOME AS A PREDICTOR OF BIOLOGICAL AGING PLPBP, PLCG1, PLA2G1B TSHR 2218/4885TP53 2672/4885EGLN1 758/4885
US-20260091051-A1 USE OF NMN FOR THE PREVENTION AND/OR TREATMENT OF PAIN, AND CORRESPONDING COMPOSITIONS SCN1A, CHRNA1, SCN1B TSHR 1674/4885TP53 4675/4885EGLN1 2251/4885
US-20120231972-A1 Probe Compound for Detecting and Isolating Enzymes and Means and Methods Using the Same SI, GUSB, MPI TSHR 4023/4885TP53 1528/4885EGLN1 2017/4885
US-20250361531-A1 MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS HSD17B10, HSD17B12, HADHB TSHR 4441/4885TP53 4590/4885EGLN1 668/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.