SCHEMBL28822437

SCHEMBL28822437

CC(=O)Oc1nccnc1Oc1ccccc1F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
MAPK8 P45983 1/20 0.44
GCK P35557 1/20 0.44
HTR1A P08908 1/20 0.43
SLC6A2 P23975 1/20 0.43
SLC6A4 P31645 1/20 0.43
ALDH1A1 P00352 3/20 0.42
ESR1 P03372 2/20 0.42
PARP10 Q53GL7 1/20 0.42
CXCL8 P10145 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.41
MAPK1 P28482 1/20 0.41
KDM4E B2RXH2 2/20 0.40
MRGPRX1 Q96LB2 1/20 0.40
TRPA1 O75762 1/20 0.40
KMT2A Q03164 1/20 0.40
ITGB3 P05106 1/20 0.40
ITGA2B P08514 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28033082 0.79 CYP1A2 (0.43) MAPTRAB9ASMN1; SMN2KDM4ETRPA1
SCHEMBL8143090 0.79 TDP1 (0.53) MAPTMAPK8ALDH1A1ESR1KDM4E
SCHEMBL1291161 0.78 L3MBTL1 (0.43) MAPTNPC1RAB9AMAPK8ALDH1A1
SCHEMBL28033079 0.78 MAPT (0.49) MAPTNPC1RAB9AMAPK8GCK
SCHEMBL247351 0.77 PTGS2 (0.57) MAPTALDH1A1ESR1PARP10CXCL8
SCHEMBL27569231 0.77 PARP10 (0.51) MAPTNPC1RAB9AMAPK8GCK
Ammonia Solution, Strong SCHEMBL4479016 0.76 PTGS2 (0.55) MAPTALDH1A1ESR1PARP10CXCL8
SCHEMBL28822439 0.75 CXCL8 (0.56) MAPTNPC1RAB9AMAPK8GCK
SCHEMBL28031195 0.75 P2RY1 (0.42) ALDH1A1KDM4EMRGPRX1KMT2AHPGD
SCHEMBL10881331 0.73 KDM4E (0.51) ALDH1A1ESR1MAPK1KDM4EITGB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104961691-A Preparation method of 3-(2-fluorophenoxy) pyrazine-2-carboxylic acid CHANGSHA SHENCHENG BIOTECHNOLOGY CO LTD 2015-10-07 CN disclosed