Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 4/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2875589 | 0.87 | HTR2A (0.44) | HTR2AMCHR1FPR2PROKR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2840414 | 0.83 | ALDH1A1 (0.39) | KDM4EALDH1A1SMN1; SMN2HRH3 | |
| SCHEMBL2838582 | 0.81 | MCHR1 (0.39) | HTR2AHTR2CSLC6A5MCHR1FPR2 | |
| SCHEMBL2841183 | 0.81 | HTR2A (0.40) | HTR2AHTR2CSLC6A5MCHR1FPR2 | |
| Hydrochloric Acid SCHEMBL2838760 | 0.80 | SLC6A2 (0.34) | HTR2AHTR2CMAPTSMN1; SMN2SLC6A4 | |
| Hydrochloric Acid SCHEMBL2843992 | 0.79 | MCHR1 (0.39) | HTR2AMCHR1 | |
| SCHEMBL2836555 | 0.79 | KDM4E (0.38) | FPR2PROKR1KDM4EALDH1A1SLC6A4 | |
| SCHEMBL2844196 | 0.79 | DDB1 (0.38) | FPR2PROKR1KDM4EALDH1A1MAPT | |
| SCHEMBL2868853 | 0.79 | ROCK2 (0.32) | HTR2AHTR2CMCHR1ALDH1A1 | |
| SCHEMBL3074628 | 0.78 | SLC6A4 (0.45) | HTR2AHTR2CSLC6A5FPR2PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217031-B2 | Heteroaryl derivatives | NIPPON SHINYAKU CO., LTD. (JP) | 2012-07-10 | — | — | US | disclosed |
| US-20100048537-A1 | HETEROARYL DERIVATIVES | NIPPON SHINYAKU CO., LTD. (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2141168-A1 | HETEROARYL DERIVATIVES | Nippon Shinyaku Co., Ltd. (JP) | 2010-01-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048537-A1 | HETEROARYL DERIVATIVES | OPRD1, OPRM1, OPRK1 | HTR2A 28/4885HTR2C 6/4885SLC6A5 278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.