Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21463384 | 0.76 | TDO2 (0.46) | MAP4K4PIK3CB | |
| SCHEMBL28488492 | 0.73 | IDO1 (0.39) | MAP4K4ALOX5APFEN1FYNMAPK10 | |
| SCHEMBL30615364 | 0.73 | IDO1 (0.39) | MAP4K4ALOX5APFEN1FYNMAPK10 | |
| SCHEMBL5700203 | 0.73 | PLAU (0.41) | MAP4K4PTGS1PTGS2 | |
| SCHEMBL3491279 | 0.71 | PTGS2 (0.59) | JAK2PTGS1PTGS2 | |
| Dimethyl Sulfone SCHEMBL28028274 | 0.71 | ALDH1A1 (0.54) | PTGS1PTGS2 | |
| SCHEMBL2643084 | 0.70 | L3MBTL1 (0.42) | MAP4K4ROCK1PIK3C3PIK3CDPIP5K1C | |
| SCHEMBL15550019 | 0.70 | HRH3 (0.44) | ROCK1PIK3CDPIP5K1CPIK3CBPI4KA | |
| SCHEMBL12075926 | 0.69 | PTGS2 (0.34) | ROCK1PIK3C3PIK3CDPIP5K1CPIK3CB | |
| SCHEMBL30808436 | 0.69 | ALDH1A1 (0.53) | JAK2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105431419-A | Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection | HOFFMANN-LA ROCHE AG | 2016-03-23 | — | — | CN | disclosed |