Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL711254 | 0.83 | NFE2L2 (0.55) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL711255 | 0.83 | NFE2L2 (0.55) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL28825496 | 0.79 | RAB9A (0.52) | NPC1RAB9AMEN1KMT2ANFE2L2 | |
| SCHEMBL28825645 | 0.79 | RAB9A (0.47) | NPC1RAB9AMEN1KMT2ANFE2L2 | |
| SCHEMBL427375 | 0.78 | NPC1 (0.61) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL28825433 | 0.78 | NPC1 (0.42) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL28825486 | 0.77 | NFE2L2 (0.47) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL3300301 | 0.76 | NFE2L2 (0.71) | NPC1RAB9ANFE2L2PKMCYP1A2 | |
| SCHEMBL28825636 | 0.75 | NFE2L2 (0.55) | NPC1RAB9AMEN1KMT2ANFE2L2 | |
| SCHEMBL28517481 | 0.75 | PTGS1 (0.50) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | disclosed |