Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28686608 | 0.81 | GRIN2B (0.37) | NFE2L2GRIN1GRIN2B | |
| SCHEMBL28825574 | 0.77 | GRIN1 (0.37) | GRIN1GRIN2B | |
| SCHEMBL28825619 | 0.75 | GRIN2B (0.37) | NFE2L2GRIN1GRIN2B | |
| SCHEMBL21020970 | 0.74 | ALDH1A1 (0.42) | NFE2L2 | |
| SCHEMBL5251881 | 0.73 | PTGS1 (0.42) | NFE2L2BACE1 | |
| SCHEMBL28825635 | 0.73 | KCNH2 (0.41) | GRIN1GRIN2B | |
| SCHEMBL28825504 | 0.73 | ALOX5 (0.42) | NFE2L2GRIN1GRIN2B | |
| SCHEMBL28825624 | 0.72 | GRIN2B (0.39) | NFE2L2GRIN1GRIN2B | |
| SCHEMBL16954998 | 0.69 | CES2 (0.48) | NFE2L2GRIN1GRIN2B | |
| SCHEMBL28825503 | 0.69 | MEN1 (0.41) | NFE2L2GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | disclosed |