Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | NNMT | P40261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28887386 | 0.89 | SIRT3 (0.40) | IRAK4ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL8011592 | 0.89 | IRAK4 (0.38) | IRAK4ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL28386490 | 0.88 | DGAT1 (0.43) | IRAK4ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL6599789 | 0.88 | ERN1 (0.43) | IRAK4ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL28882111 | 0.88 | IRAK4 (0.37) | IRAK4ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL2977145 | 0.86 | IRAK4 (0.50) | IRAK4ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL28573752 | 0.83 | CTSS (0.36) | IRAK4ALDH1A1MAPTCDC7KMT2A | |
| SCHEMBL9780987 | 0.83 | IRAK4 (0.42) | IRAK4ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL23893130 | 0.82 | GRM1 (0.37) | IRAK4CDC7NNMTSIRT3TDP1 | |
| SCHEMBL27676583 | 0.82 | IRAK4 (0.36) | IRAK4ALDH1A1MAPTKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324404-B2 | 3-thia-10-aza-phenanthrene derivatives | NYCOMED GMBH (DE) | 2012-12-04 | — | — | US | disclosed |
| US-7838521-B2 | 3-oxa-10-aza-phenanthrenes | NYCOMED GMBH (DE) | 2010-11-23 | — | — | US | disclosed |
| US-20090239895-A1 | Novel 3-thia-10-aza-phenanthrene derivatives | NYCOMED GMBH (DE) | 2009-09-24 | — | — | US | disclosed |
| US-7589205-B2 | phosphodiesterase inhibitor; antiinflammatory agent; 3-thia-10-aza-phenanthrenes and iintermediates 3-(3,4-dialkoxy-phenyl)-tetrahydro-thiopyran-4-one and 3-(3,4-dialkoxy-phenyl)-1,1-dioxo-hexahydro-1-thiopyran-4-ylamine, useful for its preparation | NYCOMED GMBH (DE) | 2009-09-15 | — | — | US | disclosed |
| CN-100528937-C | Method for producing carbonyl rest-containing organosilicon compounds | WACKER CHEMIE GMBH (DE) | 2009-08-19 | — | — | CN | disclosed |
| US-20080103168-A1 | Novel 3-Thia-10-Aza-Phenanthrene Derivatives | ATLANA PHARMA AG (DE) | 2008-05-01 | — | — | US | disclosed |
| US-20070259868-A1 | Novel 3-Oxa-10-Aza-Phenanthrenes | ALTANA PHARMA AG (DE) | 2007-11-08 | — | — | US | disclosed |
| CN-1906230-A | Method for producing carbonyl group-containing organosilicon compound | WACKER CHEMIE GMBH (DE) | 2007-01-31 | — | — | CN | disclosed |
| CN-1761787-A | Oxidation system comprising macrocyclic metal complexes, method for the production and use thereof | LANXESS B V (NL) | 2006-04-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080103168-A1 | Novel 3-Thia-10-Aza-Phenanthrene Derivatives | PDE4A, PDE4B, PDE3A | IRAK4 901/4885ALDH1A1 215/4885MAPT 4334/4885 |
| US-20070259868-A1 | Novel 3-Oxa-10-Aza-Phenanthrenes | PDE4A, PDE4B, PDE3A | IRAK4 646/4885ALDH1A1 233/4885MAPT 4613/4885 |
| US-20090239895-A1 | Novel 3-thia-10-aza-phenanthrene derivatives | PDE4A, PDE4B, PDE3A | IRAK4 901/4885ALDH1A1 215/4885MAPT 4334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.