Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 9/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1832020 | 0.92 | IRAK4 (0.44) | IRAK4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL3628076 | 0.88 | IRAK4 (0.44) | IRAK4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL458410 | 0.88 | IRAK4 (0.44) | IRAK4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL16592837 | 0.88 | IRAK4 (0.44) | IRAK4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL6951207 | 0.88 | KDM4E (0.55) | IRAK4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL30797325 | 0.88 | IRAK4 (0.44) | IRAK4KDM4EALDH1A1MAPTHPGD | |
| Hydrochloric Acid SCHEMBL30797245 | 0.86 | IRAK4 (0.43) | IRAK4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL20970373 | 0.86 | IRAK4 (0.43) | IRAK4KDM4EALDH1A1MAPTHPGD | |
| Hydrochloric Acid SCHEMBL29160773 | 0.86 | IRAK4 (0.43) | IRAK4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL2882576 | 0.86 | IRAK4 (0.44) | IRAK4KDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776847-B2 | Benzisothiazoles useful for treating or preventing HCV infection | RIGEL PHARMACEUTICALS, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-20060229294-A1 | Benzisothiazoles useful for treating or preventing HCV infection | RIGEL PHARMACEUTICALS, INC. (US) | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229294-A1 | Benzisothiazoles useful for treating or preventing HCV infection | HAVCR2, ZC3HAV1, MAVS | IRAK4 2802/4885KDM4E 2196/4885ALDH1A1 227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.