Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11258178 | 0.81 | APEX1 (0.52) | TSHRALDH1A1NPSR1POLBKDM4E | |
| SCHEMBL4500559 | 0.79 | ALDH1A1 (0.48) | TSHRALDH1A1TDP1NPSR1KDM4E | |
| SCHEMBL28829027 | 0.77 | ALDH1A1 (0.42) | TSHRALDH1A1TDP1NPSR1POLB | |
| SCHEMBL28828790 | 0.77 | TSHR (0.50) | TSHRENPP2ALDH1A1MAPK1NPSR1 | |
| SCHEMBL28828908 | 0.77 | TSHR (0.50) | TSHRENPP2ALDH1A1MAPK1NPSR1 | |
| SCHEMBL28828967 | 0.75 | TSHR (0.48) | TSHRENPP2ALDH1A1MAPK1NPSR1 | |
| SCHEMBL7641949 | 0.74 | SLC9A1 (0.57) | TSHRALDH1A1TDP1KDM4EHSD17B10 | |
| SCHEMBL9768675 | 0.73 | ALDH1A1 (0.48) | TSHRALDH1A1TDP1NPSR1POLB | |
| SCHEMBL15264258 | 0.72 | ALDH1A1 (0.78) | TSHRALDH1A1MAPK1NPSR1POLB | |
| SCHEMBL4163334 | 0.71 | ALDH1A1 (0.50) | ALDH1A1TDP1POLBKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114835688-A | Substituted 4-aryl imidazole-2-ketone derivative and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2022-08-02 | — | — | CN | disclosed |