Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | MARS1 | P56192 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11248969 | 0.86 | L3MBTL1 (0.54) | APEX1HSD17B10ALDH1A1MAPTHPGD | |
| SCHEMBL28829027 | 0.84 | ALDH1A1 (0.42) | APEX1POLBTSHRHSD17B10ALDH1A1 | |
| SCHEMBL11246384 | 0.82 | ALDH1A1 (0.47) | APEX1POLBTSHRHSD17B10ALDH1A1 | |
| SCHEMBL28828879 | 0.81 | TSHR (0.50) | POLBTSHRHSD17B10ALDH1A1MAPT | |
| SCHEMBL8559809 | 0.80 | NQO2 (0.44) | APEX1L3MBTL1 | |
| SCHEMBL9768675 | 0.80 | ALDH1A1 (0.48) | APEX1POLBTSHRHSD17B10ALDH1A1 | |
| SCHEMBL4500559 | 0.80 | ALDH1A1 (0.48) | TSHRALDH1A1MAPTNPSR1RXFP1 | |
| SCHEMBL28828981 | 0.76 | AVPR2 (0.41) | ALDH1A1MAPTNPSR1RXFP1HPGD | |
| SCHEMBL28828985 | 0.76 | AVPR2 (0.41) | ALDH1A1MAPTNPSR1RXFP1HPGD | |
| SCHEMBL28828984 | 0.73 | APEX1 (0.46) | APEX1POLBTSHRHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4330550-A | ANTICOAGULANTS AND ANALGESICS | A. NATTERMANN & CIE. GMBH (DE) | 1982-05-18 | — | — | US | claimed |
| CN-114835688-B | Substituted 4-aryl imidazole-2-ketone derivative, preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2024-08-06 | — | — | CN | disclosed |
| CN-114835688-A | Substituted 4-aryl imidazole-2-ketone derivative and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2022-08-02 | — | — | CN | disclosed |