Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | CCNC | P24863 | 2/20 | 0.34 |
| ▸ | CDK8 | P49336 | 2/20 | 0.34 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10013033 | 0.74 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2AKDM4EAPOBEC3G | |
| SCHEMBL3298820 | 0.72 | KMT2A (0.38) | ALDH1A1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL1738350 | 0.62 | CACNA1B (0.39) | ALDH1A1MEN1KMT2ACYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL1736853 | 0.61 | CACNA1B (0.39) | ALDH1A1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL15815148 | 0.61 | MAPK1 (0.42) | ALDH1A1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL5335279 | 0.61 | HPGD (0.44) | ALDH1A1MEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL13364852 | 0.60 | NR1H4 (0.47) | MEN1KMT2AMAPK1HSD17B10NPC1 | |
| SCHEMBL8989228 | 0.60 | MAP4K4 (0.53) | ALDH1A1MEN1KMT2ACYP1A2MAPK1 | |
| SCHEMBL8763523 | 0.60 | HSD11B1 (0.45) | ALDH1A1KMT2AKDM4EHPGDTSHR | |
| SCHEMBL2883034 | 0.59 | CACNA1B (0.37) | KMT2ACYP1A2CYP2C9CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2010521468-A | — | — | 2010-06-24 | — | — | JP | claimed |
| EP-2134854-A1 | TREATMENT METHOD USING EGFR ANTIBODIES AND SRC INHIBITORS AND RELATED FORMULATIONS | LUDWIG INSTITUTE FOR CANCER RESEARCH (US) | 2009-12-23 | — | — | EP | claimed |
| WO-2008115404-A1 | TREATMENT METHOD USING EGFR ANTIBODIES AND SRC INHIBITORS AND RELATED FORMULATIONS | LUDWING INSTITUTE FOR CANCER RESEARCH (US) | 2008-09-25 | — | — | WO | claimed |