Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17817949 | 0.88 | L3MBTL1 (0.45) | L3MBTL1CREBBPPIK3CDPIK3CAPIK3CB | |
| SCHEMBL2880781 | 0.86 | CDC7 (0.56) | CDC7DBF4TRPM8ALDH1A1LMNA | |
| SCHEMBL2883896 | 0.84 | TRPM8 (0.54) | CDC7DBF4TRPM8ALDH1A1LMNA | |
| SCHEMBL2880824 | 0.84 | CYP19A1 (0.42) | CDC7DBF4TRPM8ALDH1A1LMNA | |
| SCHEMBL2883830 | 0.82 | EGLN1 (0.49) | — | |
| SCHEMBL2885696 | 0.82 | TRPM8 (0.42) | CDC7DBF4TRPM8ALDH1A1LMNA | |
| SCHEMBL2881222 | 0.81 | SCN9A (0.47) | CDC7DBF4TRPM8ALDH1A1LMNA | |
| SCHEMBL2880807 | 0.80 | TRPM8 (0.58) | CDC7DBF4TRPM8CYP19A1MEN1 | |
| SCHEMBL2886810 | 0.78 | TRPM8 (0.58) | CDC7DBF4TRPM8ALDH1A1LMNA | |
| SCHEMBL2885106 | 0.78 | NPC1 (0.43) | CDC7DBF4TRPM8CSF1RL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040054177-A1 | Novel benzimidazole derivatives | MSD K.K. (JP) | 2004-03-18 | — | — | US | claimed |
| EP-3124489-B1 | THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN INC (US) | 2020-07-15 | — | — | EP | disclosed |
| EP-3124489-A1 | THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | Fibrogen, Inc. (US) | 2017-02-01 | — | — | EP | disclosed |
| EP-2016078-B1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN INC (US) | 2016-06-15 | — | — | EP | disclosed |
| US-7803807-B2 | Benzimidazole derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7696223-B2 | [(2-bromo-4-hydroxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carbonyl)-amino]-acetic acid; modulates the stability and/or activity of hypoxia inducible factor (HIF) | FIBROGEN, INC. (US) | 2010-04-13 | — | — | US | disclosed |
| US-7687514-B2 | Benzimidazole derivatives | BANYU PHARMACEUTICALS CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |
| US-20100048600-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | MSD K.K. (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2016078-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2009-01-21 | — | — | EP | disclosed |
| US-20080004309-A1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | FIBROGEN, INC. | 2008-01-03 | — | — | US | disclosed |
| WO-2007115315-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2007-10-11 | — | — | WO | disclosed |
| US-20060205750-A1 | Novel benzimidazole derivatives | MSD K.K. (JP) | 2006-09-14 | — | — | US | disclosed |
| US-7105526-B2 | Benzimidazole derivatives | BANYU PHARMACEUTICALS CO., LTD. (JP) | 2006-09-12 | — | — | US | disclosed |
| US-20040054177-A1 | Novel benzimidazole derivatives | MSD K.K. (JP) | 2004-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040054177-A1 | Novel benzimidazole derivatives | OPRM1, OPRK1, HTR7 | CDC7 1178/4885DBF4 1050/4885TRPM8 1608/4885 |
| US-20060205750-A1 | Novel benzimidazole derivatives | NPY4R, NPY5R, NPY1R | CDC7 1302/4885DBF4 609/4885TRPM8 1659/4885 |
| US-20080004309-A1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | HIF1AN, HIF1A, EGLN2 | CDC7 2482/4885DBF4 2072/4885TRPM8 3499/4885 |
| US-20100048600-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | NPY4R, NPY5R, NPY1R | CDC7 1302/4885DBF4 609/4885TRPM8 1659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.