Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL426339 | 0.85 | MAP1LC3B (0.53) | MAP1LC3BALPLL3MBTL1TDP1GAA | |
| Formic Acid Methyl Ester SCHEMBL28100816 | 0.83 | BRD4 (0.46) | MAP1LC3BGAAMAPTLMNAMAPK1 | |
| Formic Acid Methyl Ester SCHEMBL27988943 | 0.78 | SLC6A3 (0.39) | MAP1LC3BKDM1A | |
| Formic Acid Methyl Ester SCHEMBL28148965 | 0.78 | SLC6A3 (0.39) | MAP1LC3BKDM1A | |
| Formic Acid Methyl Ester SCHEMBL27988905 | 0.78 | SLC6A3 (0.39) | MAP1LC3BKDM1A | |
| SCHEMBL1780602 | 0.77 | MAPT (0.63) | MAP1LC3BALPLL3MBTL1TDP1GAA | |
| Formic Acid Methyl Ester SCHEMBL27581497 | 0.77 | NFE2L2 (0.44) | MAPTMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL428339 | 0.72 | ALDH1A1 (0.60) | L3MBTL1MAPTATMMAPK1KDM1A | |
| Formic Acid Methyl Ester SCHEMBL28100806 | 0.71 | CYP11B2 (0.46) | TDP1GAAMAPTATMLMNA | |
| SCHEMBL717834 | 0.71 | ESR2 (0.50) | MAP1LC3BALPLL3MBTL1TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105916855-B | Substituted 4, 5, 6, 7-tetrahydropyrazolo [1,5-a ] pyrazine derivatives as casein kinase 1D/E inhibitors | 百时美施贵宝公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-105916855-A | Substituted 4,5,6, 7-tetrahydropyrazolo [1,5-a ] pyrazine derivatives as casein kinase 1D/E inhibitors | 百时美施贵宝公司 | 2016-08-31 | — | — | CN | disclosed |