Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 2/20 | 0.44 |
| ▸ | CA5A | P35218 | 2/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2883842 | 0.80 | SIGMAR1 (0.36) | CA12CA2CA9SIGMAR1BCHE | |
| SCHEMBL1911254 | 0.79 | KDM4E (0.40) | ALDH1A1MEN1KMT2AEPHX1SIGMAR1 | |
| SCHEMBL7175314 | 0.79 | SIGMAR1 (0.42) | ALDH1A1SMN1; SMN2MEN1KMT2AEPHX1 | |
| Trifluoroacetic Acid SCHEMBL2883837 | 0.77 | SIGMAR1 (0.35) | SIGMAR1BCHEACHEKDM5BCHRM2 | |
| SCHEMBL10223245 | 0.77 | ACHE (0.40) | ALDH1A1POLBMEN1KMT2ACA14 | |
| SCHEMBL4374960 | 0.75 | SIGMAR1 (0.39) | ALDH1A1MEN1KMT2AEPHX1SIGMAR1 | |
| SCHEMBL3832226 | 0.75 | ALDH1A1 (0.47) | ALDH1A1POLBSMN1; SMN2CA3CA5A | |
| SCHEMBL2887269 | 0.74 | ALDH1A1 (0.56) | ALDH1A1POLBSMN1; SMN2CA3CA5A | |
| SCHEMBL13861685 | 0.73 | ALDH1A1 (0.79) | ALDH1A1POLBSMN1; SMN2CA3CA5A | |
| SCHEMBL17589297 | 0.72 | RIPK1 (0.40) | ALDH1A1MEN1KMT2AEPHX1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318750-B2 | Organic compounds | NOVARTIS AG (NL) | 2012-11-27 | — | — | US | disclosed |
| US-8258141-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-09-04 | — | — | US | disclosed |
| US-20100286126-A1 | Organic Compounds | NOVARTIS AG (CH) | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286126-A1 | Organic Compounds | CYP3A43, SLCO1B3, CYP2C19 | ALDH1A1 166/4885POLB 1432/4885SMN1; SMN2 2150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.