Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 7/20 | 0.33 |
| ▸ | TERT | O14746 | 2/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2883842 | 0.89 | SIGMAR1 (0.36) | SIGMAR1BCHEACHEKDM5BGABRR1 | |
| SCHEMBL1911254 | 0.81 | KDM4E (0.40) | SIGMAR1BCHEACHEKDM5BEPHX1 | |
| SCHEMBL7175314 | 0.81 | SIGMAR1 (0.42) | SIGMAR1BCHEACHEKDM5BEPHX1 | |
| SCHEMBL6560529 | 0.78 | ACHE (0.42) | SIGMAR1BCHEACHEKDM5BMEN1 | |
| SCHEMBL21529732 | 0.78 | CYP2C9 (0.52) | EPHX1MEN1KMT2AALDH1A1 | |
| SCHEMBL13298011 | 0.77 | ACHE (0.44) | SIGMAR1BCHEACHEKDM5BMEN1 | |
| SCHEMBL940021 | 0.76 | ALDH1A1 (0.46) | EPHX1TERTMEN1KMT2AALDH1A1 | |
| SCHEMBL25230992 | 0.75 | SIGMAR1 (0.46) | SIGMAR1BCHEACHEKDM5BMEN1 | |
| SCHEMBL5258395 | 0.75 | KDM4E (0.46) | SIGMAR1BCHEACHEKDM5BMEN1 | |
| SCHEMBL2883840 | 0.75 | ALDH1A1 (0.46) | SIGMAR1BCHEACHEKDM5BEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292604-B1 | 2-AMINOCARBONYL-9H-PURINE DERIVATIVES | PFIZER LTD (GB) | 2009-05-13 | — | — | EP | disclosed |
| EP-1292604-B1 | 2-AMINOCARBONYL-9H-PURINE DERIVATIVES | PFIZER LTD (GB) | 2009-05-13 | — | — | EP | disclosed |
| US-7094769-B2 | 2-aminocarbonyl-9H-purine derivatives | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |
| US-20060122145-A1 | 2-Aminocarbonyl-9H-purine derivatives | PFIZER INC | 2006-06-08 | — | — | US | disclosed |
| US-6753322-B2 | 2-aminocarbonyl-9H-purine derivatives | PFIZER INC | 2004-06-22 | — | — | US | disclosed |
| US-20040077584-A1 | 2-Aminocarbonyl-9H-purine derivatives | PFIZER INC | 2004-04-22 | — | — | US | disclosed |
| US-20020058641-A1 | 2-aminocarbonyl-9H-purine derivatives | PFIZER INC. | 2002-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122145-A1 | 2-Aminocarbonyl-9H-purine derivatives | PNP, NUDT1, SLC29A2 | SIGMAR1 3232/4885BCHE 1680/4885ACHE 2488/4885 |
| US-20040077584-A1 | 2-Aminocarbonyl-9H-purine derivatives | PNP, NUDT1, SLC29A2 | SIGMAR1 2955/4885BCHE 1776/4885ACHE 2579/4885 |
| US-20020058641-A1 | 2-aminocarbonyl-9H-purine derivatives | PNP, NUDT1, SLC29A1 | SIGMAR1 2502/4885BCHE 1892/4885ACHE 2540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.