Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA4 | P22748 | 2/20 | 0.48 |
| ▸ | CA6 | P23280 | 2/20 | 0.48 |
| ▸ | CA5A | P35218 | 2/20 | 0.48 |
| ▸ | CA7 | P43166 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.48 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24812776 | 0.87 | LMNA (0.45) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL25496472 | 0.79 | LMNA (0.57) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL13284033 | 0.76 | NOTUM (0.40) | — | |
| SCHEMBL11837322 | 0.73 | LMNA (0.67) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL27968997 | 0.73 | LMNA (0.67) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL11837318 | 0.73 | LMNA (0.67) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL24495277 | 0.73 | TMEM97 (0.57) | TMEM97SIGMAR1L3MBTL1HTR1AADRA2A | |
| SCHEMBL26923080 | 0.72 | HSP90AA1 (0.40) | LMNA | |
| SCHEMBL5721978 | 0.72 | HDAC8 (0.49) | LMNAAKR1B10AKR1B1ALDH1A1PTGER1 | |
| SCHEMBL21800296 | 0.72 | ABHD6 (0.55) | TMEM97SIGMAR1L3MBTL1HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114901315-A | Fibroblast Activation Protein (FAP) -targeted imaging and treatment of cancer and other fibrotic and inflammatory diseases | 普渡研究基金会 | 2022-08-12 | — | — | CN | disclosed |