Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 2/20 | 0.40 |
| ▸ | CA5A | P35218 | 2/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23148225 | 0.87 | CA2 (0.48) | CA2ALDH1A1POLBSMN1; SMN2KMT2A | |
| SCHEMBL31194869 | 0.86 | CA2 (0.53) | CA2ALDH1A1POLBSMN1; SMN2KMT2A | |
| SCHEMBL26894046 | 0.85 | CA2 (0.46) | CA2ALDH1A1POLBSMN1; SMN2KMT2A | |
| SCHEMBL8241782 | 0.85 | CA2 (0.46) | CA2ALDH1A1POLBSMN1; SMN2KMT2A | |
| SCHEMBL14791601 | 0.81 | — | — | |
| SCHEMBL31326896 | 0.81 | — | — | |
| SCHEMBL10757374 | 0.81 | ALDH1A1 (0.50) | CA2ALDH1A1POLBSMN1; SMN2KMT2A | |
| SCHEMBL20582657 | 0.81 | CA2 (0.42) | CA2ALDH1A1POLBSMN1; SMN2KMT2A | |
| SCHEMBL6643083 | 0.81 | CA2 (0.42) | CA2ALDH1A1POLBSMN1; SMN2KMT2A | |
| SCHEMBL8496257 | 0.81 | CA2 (0.42) | CA2ALDH1A1POLBSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116693540-A | Synthesis method of sitagliptin intermediate | 江苏八巨药业有限公司 | 2023-09-05 | — | — | CN | disclosed |
| CN-112358484-B | Preparation method of sitagliptin intermediate | 江苏八巨药业有限公司 | 2022-04-19 | — | — | CN | disclosed |
| US-8715395-B2 | Fluorinated metal-organic frameworks for hydrocarbon storage | UNIVERSITY OF NORTH TEXAS (US) | 2014-05-06 | — | — | US | disclosed |
| US-8715395-B2 | Fluorinated metal-organic frameworks for hydrocarbon storage | UNIVERSITY OF NORTH TEXAS (US) | 2014-05-06 | — | — | US | disclosed |
| EP-1761532-B1 | AMINOCYCLOHEXANES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME (US) | 2013-04-10 | — | — | EP | disclosed |
| US-8343260-B2 | Fluorinated metal-organic frameworks for gas storage | UNIVERSITY OF NORTH TEXAS (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343260-B2 | Fluorinated metal-organic frameworks for gas storage | UNIVERSITY OF NORTH TEXAS (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343260-B2 | Fluorinated metal-organic frameworks for gas storage | UNIVERSITY OF NORTH TEXAS (US) | 2013-01-01 | — | — | US | disclosed |
| US-20120118153-A1 | FLUORINATED METAL-ORGANIC FRAMEWORKS FOR HYDROCARBON STORAGE | THE UNIVERSITY OF NORTH TEXAS (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120118153-A1 | FLUORINATED METAL-ORGANIC FRAMEWORKS FOR HYDROCARBON STORAGE | THE UNIVERSITY OF NORTH TEXAS (US) | 2012-05-17 | — | — | US | disclosed |
| US-20100282080-A1 | FLUORINATED METAL-ORGANIC FRAMEWORKS FOR GAS STORAGE | UNIVERSITY OF NORTH TEXAS | 2010-11-11 | — | — | US | disclosed |
| US-20100282080-A1 | FLUORINATED METAL-ORGANIC FRAMEWORKS FOR GAS STORAGE | UNIVERSITY OF NORTH TEXAS | 2010-11-11 | — | — | US | disclosed |
| US-20100282080-A1 | FLUORINATED METAL-ORGANIC FRAMEWORKS FOR GAS STORAGE | UNIVERSITY OF NORTH TEXAS | 2010-11-11 | — | — | US | disclosed |
| EP-1761532-A4 | AMINOCYCLOHEXANES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2009035664-A1 | FLUORINATED METAL-ORGANIC FRAMEWORKS FOR GAS STORAGE | UNIVERSITY OF NORTH TEXAS (US) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009035664-A1 | FLUORINATED METAL-ORGANIC FRAMEWORKS FOR GAS STORAGE | UNIVERSITY OF NORTH TEXAS (US) | 2009-03-19 | — | — | WO | disclosed |
| US-7482336-B2 | Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-20070254865-A1 | 2-substituted phenyl-5-fused heteroaryl cyclohexylamines; may be coadministered with metformin; non-insulin dependent diabetes | MERCK SHARP & DOHME LLC | 2007-11-01 | — | — | US | disclosed |
| EP-1761532-A1 | AMINOCYCLOHEXANES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | Merck & Co., Inc. (US) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006009886-A1 | AMINOCYCLOHEXANES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2006-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120118153-A1 | FLUORINATED METAL-ORGANIC FRAMEWORKS FOR HYDROCARBON STORAGE | TRPM8, TRPA1, PFAS | CA2 497/4885ALDH1A1 4413/4885POLB 2778/4885 |
| US-20070254865-A1 | 2-substituted phenyl-5-fused heteroaryl cyclohexylamines; may be coadministered with metformin; non-insulin dependent diabetes | DPP4, DPP3, DPP7 | CA2 1114/4885ALDH1A1 1103/4885POLB 2641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.