Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NQO1 | P15559 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28446989 | 0.81 | LMNA (0.39) | CYP1A2LMNANQO1NPSR1MAOB | |
| SCHEMBL28340802 | 0.81 | LMNA (0.39) | CYP1A2LMNANQO1PLAUNPSR1 | |
| SCHEMBL28523610 | 0.79 | LMNA (0.38) | CYP1A2LMNANQO1NPSR1ALOX15 | |
| SCHEMBL28896473 | 0.78 | LMNA (0.40) | CYP1A2LMNANQO1SIRT6ALOX15 | |
| SCHEMBL14639041 | 0.78 | NQO1 (0.39) | CYP1A2LMNANQO1NPSR1ALOX15 | |
| SCHEMBL28846885 | 0.77 | LMNA (0.40) | LMNANQO1L3MBTL1ALDH1A1POLB | |
| SCHEMBL28532598 | 0.73 | LMNA (0.39) | CYP1A2LMNANQO1NPSR1SIRT6 | |
| SCHEMBL3216531 | 0.73 | PLAU (0.40) | CYP1A2LMNAPLAUL3MBTL1ALDH1A1 | |
| SCHEMBL17764516 | 0.72 | CYP1A2 (0.36) | CYP1A2LMNANQO1NPSR1L3MBTL1 | |
| SCHEMBL28697197 | 0.71 | DGAT1 (0.43) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108473464-B | Isoindolinone inhibitors of MDM2-P53 interaction with anti-cancer activity | 阿斯泰克斯治疗有限公司 | 2022-08-23 | — | — | CN | disclosed |