Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | NQO1 | P15559 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 3/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28340802 | 0.81 | LMNA (0.39) | LMNANQO1PARP10ALOX15GLA | |
| SCHEMBL28846986 | 0.81 | CYP1A2 (0.39) | LMNANQO1MAOBALOX15GLA | |
| SCHEMBL28523610 | 0.79 | LMNA (0.38) | LMNANQO1PARP10ALOX15GLA | |
| SCHEMBL28896473 | 0.78 | LMNA (0.40) | LMNANQO1AOC3PARP10ALOX15 | |
| SCHEMBL14639041 | 0.78 | NQO1 (0.39) | LMNANQO1PARP10ALOX15CYP1A2 | |
| SCHEMBL28846885 | 0.77 | LMNA (0.40) | LMNANQO1AOC3PARP10 | |
| SCHEMBL19581865 | 0.76 | APLNR (0.33) | APLNRAGBL2CYP1A2 | |
| SCHEMBL19581868 | 0.76 | APLNR (0.33) | APLNRAGBL2CYP1A2 | |
| SCHEMBL26970086 | 0.74 | HTT (0.44) | APLNRMAOBAGBL2 | |
| SCHEMBL28697197 | 0.71 | DGAT1 (0.43) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111556871-B | 1H-pyrazolo [4,3-b ] pyridines as PDE1 inhibitors | H.隆德贝克有限公司 | 2023-07-07 | — | — | CN | disclosed |
| CN-111556871-A | 1H-pyrazolo [4,3-b ] pyridines as PDE1 inhibitors | H.隆德贝克有限公司 | 2020-08-18 | — | — | CN | disclosed |