Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28170878 | 0.80 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2ARXRACDC25B | |
| SCHEMBL27999335 | 0.74 | MEN1 (0.49) | MAPTALOX15TSHRHPGDTP53 | |
| SCHEMBL13268257 | 0.72 | CA12 (0.51) | MAPTALOX15TSHRALDH1A1KDM4E | |
| SCHEMBL27966618 | 0.71 | CASP1 (0.44) | MAPTALOX15TSHRHPGDALDH1A1 | |
| SCHEMBL28859458 | 0.70 | SLC7A5 (0.41) | NPC1MEN1KMT2ACA12CA1 | |
| SCHEMBL27983812 | 0.70 | ALDH1A1 (0.53) | MAPTTSHRHPGDALDH1A1GAA | |
| SCHEMBL28401248 | 0.69 | PKM (0.43) | MAPTALOX15TSHRHPGDALDH1A1 | |
| SCHEMBL13270403 | 0.69 | SRD5A2 (0.35) | NPC1SMN1; SMN2CA12CA1CA2 | |
| SCHEMBL27836513 | 0.69 | ALDH1A1 (0.58) | MAPTALOX15TSHRHPGDALDH1A1 | |
| SCHEMBL28143550 | 0.69 | TSHR (0.36) | MAPTALOX15TSHRALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108347943-A | HEPATITIS B CORE PROTEIN MODULATORS | 组装生物科学股份有限公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-108026052-A | 5-hydroxyalkyl benzimidazoles as mIDH1 inhibitors | 拜耳制药股份公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-107949557-A | 2 aryl and 2 aralkyl benzimidazoles as mIDH1 inhibitor | 拜耳制药股份公司 | 2018-04-20 | — | — | CN | disclosed |
| CN-107810176-A | N menthyl benzimidazoles compounds as mIDH1 inhibitor | 拜耳制药股份公司 | 2018-03-16 | — | — | CN | disclosed |
| CN-107108554-A | It is used for the phenyl amino benzimidazole of 1 cyclohexyl 2 for treating tumour as MIDH1 inhibitor | 拜耳医药股份有限公司 | 2017-08-29 | — | — | CN | disclosed |