Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.37 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F12 | P00748 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15880488 | 0.85 | ALDH1A1 (0.46) | HSD17B10LRRK2ALDH1A1MAPTGAA | |
| SCHEMBL27716616 | 0.74 | GAA (0.55) | ALDH1A1MAPTGAAKDM4EKMT2A | |
| SCHEMBL9553582 | 0.72 | GAA (0.58) | ALDH1A1MAPTGAAKDM4EUSP2 | |
| SCHEMBL28109363 | 0.72 | LMNA (0.49) | ALDH1A1MAPTGAAKDM4EUSP2 | |
| SCHEMBL27763708 | 0.72 | SMN1; SMN2 (0.41) | HSD17B10ALDH1A1MAPTGAATRPV1 | |
| SCHEMBL28455478 | 0.71 | EPHX2 (0.39) | LRRK2ALDH1A1MAPTGAACSNK2A2 | |
| SCHEMBL27763673 | 0.71 | TSHR (0.44) | HSD17B10LRRK2ALDH1A1GAAKDM4E | |
| SCHEMBL27785587 | 0.71 | ALDH1A1 (0.41) | ALDH1A1MAPTGAATRPV1KDM4E | |
| SCHEMBL27874078 | 0.71 | CHRNB2 (0.44) | ALDH1A1MAPTGAATRPV1KDM4E | |
| SCHEMBL27632840 | 0.70 | CES1 (0.52) | HSD17B10CES1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107207521-A | Substituted bridged urea analogs as sirtuin modulators | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-107207509-A | Substituted bridged ring urea analogs as sirtuin modulators | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 2017-09-26 | — | — | CN | disclosed |