Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 9/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27832425 | 0.83 | MEN1 (0.50) | GAASMN1; SMN2NPC1RAB9APKM | |
| SCHEMBL31286005 | 0.83 | RAB9A (0.59) | GAASMN1; SMN2NPC1RAB9APKM | |
| SCHEMBL1011540 | 0.83 | RAB9A (0.59) | GAASMN1; SMN2NPC1RAB9APKM | |
| SCHEMBL27763673 | 0.83 | TSHR (0.44) | GAASMN1; SMN2RAB9AKDM4EKMT2A | |
| SCHEMBL27874078 | 0.83 | CHRNB2 (0.44) | GAARAB9AKDM4EMAPTKMT2A | |
| SCHEMBL27668109 | 0.81 | GAA (0.55) | GAASMN1; SMN2P2RX7NPC1RAB9A | |
| SCHEMBL27785586 | 0.81 | GOT1 (0.40) | GAASMN1; SMN2RAB9AKDM4EMAPT | |
| SCHEMBL5523952 | 0.79 | GAA (0.65) | GAASMN1; SMN2P2RX7NPC1RAB9A | |
| SCHEMBL28233819 | 0.79 | RAB9A (0.56) | SMN1; SMN2NPC1RAB9AMAPTKMT2A | |
| SCHEMBL27792353 | 0.78 | P2RX7 (0.55) | GAASMN1; SMN2P2RX7NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105392788-B | Substituted bridging urea analog as Sirtuin conditioning agent | 葛兰素史密斯克莱有限责任公司 | 2018-10-23 | — | — | CN | disclosed |
| CN-107207496-A | Substituted bridged ring urea analogs as sirtuin modulators | 葛兰素史密斯克莱有限责任公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-107108593-A | Substituted oxazole and thiazole-based carboxamide and urea derivatives as vanilloid receptor ligands II | 美迪福伦DBT有限公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-102725291-B | Bicyclic pyridine and relevant analog as Sirtuin regulator | 西特里斯药业公司 | 2016-12-21 | — | — | CN | disclosed |
| CN-105392788-A | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC | 2016-03-09 | — | — | CN | disclosed |
| CN-101595102-B | Diaryl ether urea compounds | PFIZER PROD INC | 2013-08-07 | — | — | CN | disclosed |
| CN-101146786-B | Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase | JANSSEN PHARMACEUTICA NV | 2013-03-27 | — | — | CN | disclosed |
| CN-102725291-A | Bicyclic pyridines and analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2012-10-10 | — | — | CN | disclosed |
| CN-101595102-A | Diaryl ether urea compounds | PFIZER PROD INC (US) | 2009-12-02 | — | — | CN | disclosed |
| CN-101146786-A | Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase | JANSSEN PHARMACEUTICA NV (BE) | 2008-03-19 | — | — | CN | disclosed |