Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Primidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.82 |
| ▸ | TSHR | P16473 | 2/20 | 0.82 |
| ▸ | MEN1 | O00255 | 1/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.82 |
| ▸ | POLB | P06746 | 1/20 | 0.82 |
| ▸ | APEX1 | P27695 | 1/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.82 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | MMP3 | P08254 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Primidone SCHEMBL34221 | 0.91 | KMT2A (1.00) | KMT2ATSHRMEN1CYP1A2POLB | |
| Phenobarbital SCHEMBL1171829 | 0.84 | KMT2A (0.87) | KMT2ATSHRMEN1CYP1A2POLB | |
| Phenytoin SCHEMBL8662692 | 0.78 | KMT2A (0.75) | KMT2ATSHRMEN1CYP1A2POLB | |
| SCHEMBL8184877 | 0.74 | MEN1 (0.70) | KMT2ATSHRMEN1CYP1A2POLB | |
| Primidone SCHEMBL7310584 | 0.74 | KMT2A (0.63) | KMT2ATSHRMEN1CYP1A2POLB | |
| Primidone SCHEMBL3175374 | 0.74 | POLB (0.68) | KMT2ATSHRMEN1CYP1A2POLB | |
| Phenobarbital SCHEMBL19991483 | 0.74 | MMP2 (0.75) | KMT2ATSHRMEN1CYP1A2POLB | |
| Phenobarbital SCHEMBL18825042 | 0.73 | MMP2 (0.80) | KMT2ATSHRMEN1CYP1A2POLB | |
| Phenobarbital SCHEMBL16583 | 0.73 | MMP2 (0.80) | KMT2ATSHRMEN1CYP1A2POLB | |
| Phenobarbital SCHEMBL28099657 | 0.73 | MMP2 (0.80) | KMT2ATSHRMEN1CYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107427458-A | intravenous ganaxolone formulations and their use in the treatment of status epilepticus and other seizure disorders | 马瑞纳斯制药公司 | 2017-12-01 | — | — | CN | disclosed |