Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Primidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.44 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.44 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | APEX1 | P27695 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | MMP2 | P08253 | 5/20 | 0.50 |
| ▸ | MMP9 | P14780 | 5/20 | 0.50 |
| ▸ | MMP3 | P08254 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenobarbital SCHEMBL1171829 | 0.85 | KMT2A (0.87) | POLBKMT2AMEN1CYP1A2TSHR | |
| Primidone SCHEMBL34221 | 0.82 | KMT2A (1.00) | POLBKMT2AMEN1CYP1A2TSHR | |
| Phenytoin SCHEMBL8662692 | 0.76 | KMT2A (0.75) | POLBKMT2AMEN1CYP1A2TSHR | |
| Phenobarbital SCHEMBL19991483 | 0.76 | MMP2 (0.75) | POLBKMT2AMEN1CYP1A2TSHR | |
| Phenobarbital SCHEMBL28099657 | 0.76 | MMP2 (0.80) | POLBKMT2AMEN1CYP1A2TSHR | |
| Phenobarbital SCHEMBL16583 | 0.76 | MMP2 (0.80) | POLBKMT2AMEN1CYP1A2TSHR | |
| Phenobarbital SCHEMBL18825042 | 0.76 | MMP2 (0.80) | POLBKMT2AMEN1CYP1A2TSHR | |
| Phenobarbital SCHEMBL2592325 | 0.76 | MMP2 (0.80) | POLBKMT2AMEN1CYP1A2TSHR | |
| Butabarbital SCHEMBL79255 | 0.76 | CYP3A4 (0.71) | POLBMMP2MMP9MMP3KDM4E | |
| Butabarbital SCHEMBL79254 | 0.76 | CYP3A4 (0.71) | POLBMMP2MMP9MMP3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100021519-A1 | Compositions and Methods for Treating or Preventing Diseases of Body Passageways | SHENOY NARMADA | 2010-01-28 | — | — | US | disclosed |
| EP-2019649-A1 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING DISEASES OF BODY PASSAGEWAYS | Shenoy, Narmada R. (US) | 2009-02-04 | — | — | EP | disclosed |
| WO-2007127488-A1 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING DISEASES OF BODY PASSAGEWAYS | SHENOY NARMADA R (US) | 2007-11-08 | — | — | WO | disclosed |
| US-20060121088-A1 | Compositions and methods for treating or preventing diseases of body passageways | ANGIOTECH INTERNATIONAL AG (CH) | 2006-06-08 | — | — | US | disclosed |
| EP-1616563-A2 | Perivascular administration of anti-angiogenic factors for treating or preventing vascular diseases | Angiotech Pharmaceuticals, Inc. (CA) | 2006-01-18 | — | — | EP | disclosed |
| EP-0914102-B8 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING DISEASES OF BODY PASSAGEWAYS | ANGIOTECH PHARM INC (CA) | 2005-11-02 | — | — | EP | disclosed |
| US-20050192235-A1 | Compositions and methods for treating or preventing diseases of body passageways | ANGIOTECH INTERNATIONAL AG | 2005-09-01 | — | — | US | disclosed |
| US-20050137148-A1 | Compositions and methods for treating or preventing diseases of body passageways | ANGIOTECH INTERNATIONAL AG | 2005-06-23 | — | — | US | disclosed |
| US-20050129736-A1 | Compositions and methods for treating or preventing diseases of body passageways | ANGIOTECH INTERNATIONAL AG | 2005-06-16 | — | — | US | disclosed |
| US-20050107291-A1 | Compositions and methods for treating or preventing diseases of body passageways | ANGIOTECH INTERNATIONAL AG | 2005-05-19 | — | — | US | disclosed |
| US-20050101635-A1 | Compositions and methods for treating or preventing diseases of body passageways | ANGIOTECH INTERNATIONAL AG | 2005-05-12 | — | — | US | disclosed |
| US-20050096388-A1 | Compositions and methods for treating or preventing diseases of body passageways | ANGIOTECH INTERNATIONAL AG | 2005-05-05 | — | — | US | disclosed |
| US-20040224023-A1 | Compositions and methods for treating or preventing diseases of body passageways | ANGIOTECH PHARMACEUTICALS, INC. (CA) | 2004-11-11 | — | — | US | disclosed |
| US-6759431-B2 | TREATING OR PREVENTING VASCULAR DISEASES ASSOCIATED WITH BODY PASSAGEWAYS, BY DELIVERING TO AN EXTERNAL PORTION OF THE BODY PASSAGEWAY A COMPOSITION COMPRISING PACLITAXEL, OR AN ANALOGUE OR DERIVATIVE THEREOF | ANGIOTECH PHARMACEUTICALS, INC. (CA) | 2004-07-06 | — | — | US | disclosed |
| US-20020052404-A1 | Compositions and methods for treating or preventing diseases of body passageways | ANGIOTECH PHARMACEUTICALS, INC. (CA) | 2002-05-02 | — | — | US | disclosed |
| EP-0914102-A1 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING DISEASES OF BODY PASSAGEWAYS | Angiotech Pharmaceuticals, Inc. (CA) | 1999-05-12 | — | — | EP | disclosed |
| WO-1997045105-A1 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING DISEASES OF BODY PASSAGEWAYS | ANGIOTECH PHARMACEUTICALS, INC. (CA) | 1997-12-04 | — | — | WO | disclosed |