Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | BPTF | Q12830 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28216623 | 0.78 | TDP1 (0.37) | TLR8ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL18023036 | 0.78 | TLR8 (0.50) | TLR8ALDH1A1MAPTMEN1MAPK1 | |
| SCHEMBL28211459 | 0.74 | TSHR (0.47) | ALDH1A1KDM4EMAPTMEN1POLB | |
| SCHEMBL15409043 | 0.71 | NQO1 (0.41) | ALDH1A1KDM4EMAPTMEN1POLB | |
| SCHEMBL24313567 | 0.69 | L3MBTL1 (0.40) | ALDH1A1KDM4EMAPTMEN1POLB | |
| SCHEMBL24327309 | 0.69 | LMNA (0.36) | ALDH1A1KDM4EMAPTMEN1POLB | |
| SCHEMBL28216611 | 0.67 | CA12 (0.50) | ALDH1A1KDM4EMAPTMEN1HPGD | |
| SCHEMBL24196687 | 0.65 | ALDH1A1 (0.39) | TLR8ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL28203968 | 0.65 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPTTSHRCYP3A4 | |
| SCHEMBL7223535 | 0.65 | TAAR1 (0.33) | KDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104540826-B | Spiro-fused piperidine derivatives useful as inhibitors of extrarenal potassium channels | 默沙东公司 | 2018-04-20 | — | — | CN | disclosed |