Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL1325312 | 0.80 | HTT (0.40) | SMN1; SMN2FFAR1LMNACYP1A2RAB9A | |
| Adipic Acid SCHEMBL1326117 | 0.74 | HTT (0.38) | SMN1; SMN2LMNAKDM4EHTTMAPT | |
| Sebacic Acid SCHEMBL1325801 | 0.73 | NAAA (0.39) | LMNAALDH1A1HTTMAPTNAAA | |
| Succinic Acid SCHEMBL1326223 | 0.69 | ALDH1A1 (0.45) | SMN1; SMN2FFAR1LMNACYP1A2RAB9A | |
| Biphenyl SCHEMBL4132218 | 0.67 | FFAR1 (0.71) | SMN1; SMN2FFAR1LMNACYP1A2RAB9A | |
| SCHEMBL13723001 | 0.66 | MAOA (0.33) | SMN1; SMN2CYP1A2ALDH1A1CYP2C19KMT2A | |
| SCHEMBL28700819 | 0.65 | PPARG (0.34) | NAAA | |
| Glutarate SCHEMBL11316852 | 0.65 | SMN1; SMN2 (0.42) | SMN1; SMN2FFAR1LMNACYP1A2RAB9A | |
| Adipic Acid SCHEMBL1325137 | 0.65 | HDAC3 (0.44) | SMN1; SMN2FFAR1LMNACYP1A2RAB9A | |
| Succinic Acid SCHEMBL4739951 | 0.65 | LMNA (0.82) | SMN1; SMN2FFAR1LMNACYP1A2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108290392-A | Laminated body and its manufacturing method and bonding composition | 三井化学株式会社 | 2018-07-17 | — | — | CN | disclosed |