Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 4/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5331605 | 0.81 | MEN1 (0.43) | MEN1ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL2882688 | 0.81 | POLB (0.49) | MEN1ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL2887162 | 0.81 | LMNA (0.45) | MEN1ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL2887501 | 0.77 | MEN1 (0.59) | MEN1ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL2881621 | 0.72 | BRD4 (0.49) | ALDH1A1SMN1; SMN2POLBBRD4KCNH2 | |
| SCHEMBL1982991 | 0.67 | ALDH1A1 (0.59) | MEN1ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL18083010 | 0.64 | MEN1 (0.68) | MEN1ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL9588427 | 0.64 | KMT2A (0.57) | MEN1ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL23045652 | 0.64 | MEN1 (0.61) | MEN1ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL17987142 | 0.64 | CYP11B1 (0.69) | MEN1ALDH1A1KMT2ASMN1; SMN2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222421-B2 | Certain substituted ureas, as modulators of kinase activity | GILEAD CONNECTICUT, INC. (US) | 2012-07-17 | — | — | US | disclosed |
| US-8222421-B2 | Certain substituted ureas, as modulators of kinase activity | GILEAD CONNECTICUT, INC. (US) | 2012-07-17 | — | — | US | disclosed |
| US-8222421-B2 | Certain substituted ureas, as modulators of kinase activity | GILEAD CONNECTICUT, INC. (US) | 2012-07-17 | — | — | US | disclosed |
| US-20100286190-A1 | CERTAIN SUBSTITUTED UREAS, AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. | 2010-11-11 | — | — | US | disclosed |
| US-20100286190-A1 | CERTAIN SUBSTITUTED UREAS, AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. | 2010-11-11 | — | — | US | disclosed |
| US-20100286190-A1 | CERTAIN SUBSTITUTED UREAS, AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. | 2010-11-11 | — | — | US | disclosed |
| US-7777040-B2 | Certain substituted ureas, as modulators of kinase activity | CGI PHARMACEUTICALS, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-7777040-B2 | Certain substituted ureas, as modulators of kinase activity | CGI PHARMACEUTICALS, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-7777040-B2 | Certain substituted ureas, as modulators of kinase activity | CGI PHARMACEUTICALS, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| WO-2007024294-A2 | CERTAIN SUBSTITUTED UREAS, AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. (US) | 2007-03-01 | — | — | WO | disclosed |
| US-20060270702-A1 | Certain substituted ureas, as modulators of kinase activity | GILEAD CONNECTICUT, INC. | 2006-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270702-A1 | Certain substituted ureas, as modulators of kinase activity | UCK2, CHUK, TK1 | MEN1 3522/4885ALDH1A1 1183/4885KMT2A 3039/4885 |
| US-20100286190-A1 | CERTAIN SUBSTITUTED UREAS, AS MODULATORS OF KINASE ACTIVITY | UCK2, CHUK, TK1 | MEN1 3522/4885ALDH1A1 1183/4885KMT2A 3039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.