Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28630187 | 0.83 | HTR6 (0.42) | CYP2C19HTR6PLK1TDO2IDO1 | |
| SCHEMBL2887468 | 0.81 | CYP2C19 (0.45) | CYP2C19KCNH2PLK1MAPTFABP4 | |
| SCHEMBL18517038 | 0.80 | CYP2C19 (0.50) | CYP2C19KCNH2PLK1MAPT | |
| SCHEMBL2891046 | 0.78 | CYP2C19 (0.44) | CYP2C19KCNH2PLK1MAPT | |
| SCHEMBL21226008 | 0.77 | CYP2C19 (0.50) | CYP2C19KCNH2PLK1MAPTMEN1 | |
| SCHEMBL2883498 | 0.76 | CYP2C19 (0.68) | CYP2C19KCNH2 | |
| SCHEMBL8153425 | 0.76 | ALDH1A1 (0.49) | CYP2C19HTR6TDO2MAPTSMN1; SMN2 | |
| SCHEMBL10034408 | 0.75 | CYP2C19 (0.52) | CYP2C19KCNH2PLK1MAPTMEN1 | |
| SCHEMBL28631375 | 0.75 | ALDH1A1 (0.41) | CYP2C19PLK1TDO2MAPTSMN1; SMN2 | |
| SCHEMBL14774987 | 0.75 | CYP2C19 (0.66) | CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440842-B2 | Antimicrobial compounds, their synthesis and their use for treatment of mammalian infections | LEIBNIZ-INSTITUT FUER NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE E.V. HANS-KNOELL-INSTITUT (DE) | 2013-05-14 | — | — | US | claimed |
| US-20100286130-A1 | ANTIMICROBIAL COMPOUNDS, THEIR SYNTHESIS AND THEIR USE FOR TREATMENT OF MAMMALIAN INFECTIONS | LEIBNIZ-INSTITUT FUER NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE E.V. HANS-KNOELL-INSTITUT (DE) | 2010-11-11 | — | — | US | claimed |
| EP-2176248-B1 | NEW ANTIMICROBIAL COMPOUNDS, THEIR SYNTHESIS AND THEIR USE FOR TREATMENT OF MAMMALIAN INFECTIONS | LEIBNIZ INST NATURSTOFF FORSCH (DE) | 2010-09-29 | — | — | EP | claimed |
| US-8440842-B2 | Antimicrobial compounds, their synthesis and their use for treatment of mammalian infections | LEIBNIZ-INSTITUT FUER NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE E.V. HANS-KNOELL-INSTITUT (DE) | 2013-05-14 | — | — | US | disclosed |
| US-20100286130-A1 | ANTIMICROBIAL COMPOUNDS, THEIR SYNTHESIS AND THEIR USE FOR TREATMENT OF MAMMALIAN INFECTIONS | LEIBNIZ-INSTITUT FUER NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE E.V. HANS-KNOELL-INSTITUT (DE) | 2010-11-11 | — | — | US | disclosed |
| EP-2176248-B1 | NEW ANTIMICROBIAL COMPOUNDS, THEIR SYNTHESIS AND THEIR USE FOR TREATMENT OF MAMMALIAN INFECTIONS | LEIBNIZ INST NATURSTOFF FORSCH (DE) | 2010-09-29 | — | — | EP | disclosed |
| EP-2020406-A1 | New antimicrobial compounds, their synthesis and their use for treatment of mammalian infection | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. Hans-Knöll-Institut (DE) | 2009-02-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286130-A1 | ANTIMICROBIAL COMPOUNDS, THEIR SYNTHESIS AND THEIR USE FOR TREATMENT OF MAMMALIAN INFECTIONS | ARG1, ARG2, LPO | CYP2C19 1786/4885KCNH2 2697/4885HTR6 4753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.